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LRCH4 - leucine rich repeats and calponin homology domain containing 4 Gene

Also Known as LRN; LRRN1; LRRN4; PP14183

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4034

About LRCH4

This gene has 10 transcripts (splice variants), 92 orthologues and 31 paralogues. Broad expression in testis (RPKM 33.5), spleen (RPKM 31.2) and 25 other tissues.

Summary

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

LRCH4 Products (2)

mRNA	Protein	Name
NM_001289934.2	NP_001276863.1	leucine-rich repeat and calponin homology domain-containing protein 4 isoform 2
NM_002319.5	NP_002310.2	leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRCH4 Protein Structure

LRR_8

LRR_1

0
200
400
600
683 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat and calponin homology domain-containing protein 4	leucine rich repeat neuronal 4

LRCH4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRCH4	O75427	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	LRCH4	O75427	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	LRCH4	O75427	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	LRCH4	O75427	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	LRCH4	O75427	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	LRCH4	O75427	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	LRCH4	O75427	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	LRCH4	O75427	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	LRCH4	O75427	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	ELOVL7	Homo sapiens	A1L3X0	Y2H Array	32296183
Intra	LRCH4	O75427	ELOVL7	Homo sapiens	A1L3X0	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	CYB5R3	Homo sapiens	P00387	Validated Y2H	32296183
Intra	LRCH4	O75427	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	LRCH4	O75427	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	LRCH4	O75427	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	LRCH4	O75427	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	RNASEK	Homo sapiens	Q6P5S7	Validated Y2H	32296183
Intra	LRCH4	O75427	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	LRCH4	O75427	DOCK7	Homo sapiens	Q96N67	Anti Tag CoIP	24255178
Intra	LRCH4	O75427	DOCK8	Homo sapiens	Q8NF50-3	Anti Tag CoIP	32203420
Intra	LRCH4	O75427	SUGT1	Homo sapiens	Q9Y2Z0	Anti Tag CoIP	24255178
Intra	LRCH4	O75427	DOCK6	Homo sapiens	Q96HP0	Anti Tag CoIP	32203420
Intra	LRCH4	O75427	MDFI	Homo sapiens	Q99750	Y2H Pooling	16189514
Intra	LRCH4	O75427	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	LRCH4	O75427	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	LRCH4	O75427	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Brittle Cornea Syndrome 1	Brittle Cornea Syndrome Fragilitas Oculi With Joint Hyperextensibility Dysgenesis Mesodermalis Corneae Et Sclerae BCS1 Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility Ehlers-Danlos Syndrome, Type Vib, Formerly Eds6b, Formerly Type Vib Ehlers-Danlos Syndrome Eds Vib Ehlers-Danlos Syndrome Type 6b Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility Eds6b Formerly Ehlers-Danlos Syndrome Type Vib Formerly Ehlers-Danlos Syndrome Type 6 Cornea, Brittle, Syndrome Cornea, Brittle, Syndrome, Type 1 Ehlers-Danlos Syndrome 6b
Corneal Dystrophy, Posterior Polymorphous, 1	Posterior Polymorphous Corneal Dystrophy Ppcd Maumenee Corneal Dystrophy Posterior Polymorphous Corneal Dystrophy 1 PPCD1 Corneal Dystrophy, Hereditary Polymorphous Posterior Corneal Endothelial Dystrophy 1, Autosomal Dominant Schlichting Dystrophy Ched1 Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly Ched1, Formerly Hereditary Polymorphus Posterior Corneal Dystrophy Posterior Polymorphous Dystrophy Hereditary Polymorphous Posterior Corneal Dystrophy Dystrophy, Corneal, Posterior Polymorphous Dystrophy, Corneal, Posterior Polymorphous, Type 1 Polymorphous Corneal Dystrophy Corneal Endothelial Dystrophy 2
Differentiating Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07780	LRCH4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRCH4	RGD	RGD:1306145
Bos taurus	LRCH4	VGNC	VGNC:30974
Macaca mulatta	LRCH4	VGNC	VGNC:74441
Canis familiaris	LRCH4	VGNC	VGNC:42759
Mus musculus	LRCH4	MGD	MGI:1917193
Felis catus	LRCH4	VGNC	VGNC:68086
Others	LRCH4	NCBI