SUGT1 - SGT1 homolog, MIS12 kinetochore complex assembly cochaperone Gene

Also Known as SGT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10910

About SUGT1

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,652,836-52,700,909 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 4.1), testis (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

SUGT1 Products (3)

mRNA Protein Name
NM_001130912.3 NP_001124384.1 protein SGT1 homolog isoform B
NM_001320831.2 NP_001307760.1 protein SGT1 homolog isoform C
NM_006704.5 NP_006695.1 protein SGT1 homolog isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17420470 GOA
Biological Process GO Annotation Evidence References Source
involved in kinetochore assembly IMP
IMP: Inferred from mutant phenotype
15133482 GOA
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
23935490 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
23184943 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUGT1 Protein Structure

TPR_11

TPR_11: TPR repeat (25 - 76)

CS

CS: CS domain (173 - 248)

SGS

SGS: SGS domain (285 - 365)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

protein SGT1 homolog

  • SGT1, suppressor of G2 allele of SKP1

SUGT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SUGT1 Q9Y2Z0 NOD1 Homo sapiens Q9Y239
Anti Tag CoIP
17420470
Cross
SUGT1 Q9Y2Z0 sspH2 Salmonella typhimurium A0A0H3NF38
Anti Bait CoIP
21566117
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Louping Ill
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14010 SUGT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SUGT1 RGD RGD:1307550
Macaca mulatta SUGT1 VGNC VGNC:103875
Bos taurus SUGT1 VGNC VGNC:35465
Felis catus SUGT1 VGNC VGNC:65832
Mus musculus SUGT1 MGD MGI:1915205
Others SUGT1 NCBI