2. Gene
  3. SUGT1 - SGT1 homolog, MIS12 kinetochore complex assembly cochaperone Gene

SUGT1 - SGT1 homolog, MIS12 kinetochore complex assembly cochaperone Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SGT1

Gene ID: 10910 | Gene type: protein coding

About SUGT1

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,652,836-52,700,909 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 4.1), testis (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

SUGT1 Products(3)

mRNA Protein Name
NM_001130912.3 NP_001124384.1 protein SGT1 homolog isoform B
NM_001320831.2 NP_001307760.1 protein SGT1 homolog isoform C
NM_006704.5 NP_006695.1 protein SGT1 homolog isoform A

SUGT1 Protein Structure

TPR_11

TPR_11: TPR repeat (25 - 76)

CS

CS: CS domain (173 - 248)

SGS

SGS: SGS domain (285 - 365)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

protein SGT1 homolog

SGT1, suppressor of G2 allele of SKP1

Related Diseases

Diseases Alias
Louping Ill
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14010 SUGT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SUGT1 RGD RGD:1307550
Macaca mulatta SUGT1 VGNC VGNC:103875
Bos taurus SUGT1 VGNC VGNC:35465
Felis catus SUGT1 VGNC VGNC:65832
Mus musculus SUGT1 MGD MGI:1915205