GTF3C5 - general transcription factor IIIC subunit 5 Gene

Also Known as TFIIIC63; TFiiiC2-63; TFIIICepsilon

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9328

Summary

Enables RNA polymerase III general transcription initiation factor activity. Involved in transcription initiation at RNA polymerase III promoter. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in ovary (RPKM 17.0), testis (RPKM 11.6) and 25 other tissues.

GTF3C5 Products (3)

mRNA Protein Name
NM_001122823.2 NP_001116295.1 general transcription factor 3C polypeptide 5 isoform 1
NM_001286709.2 NP_001273638.1 general transcription factor 3C polypeptide 5 isoform 3
NM_012087.4 NP_036219.2 general transcription factor 3C polypeptide 5 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase III general transcription initiation factor activity IDA
IDA: Inferred from direct assay
17409385 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17409385 GOA
Cellular Component GO Annotation Evidence References Source
part of transcription factor TFIIIC complex IDA
IDA: Inferred from direct assay
17409385 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF3C5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GTF3C5 Q9Y5Q8 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
GTF3C5 Q9Y5Q8 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
GTF3C5 Q9Y5Q8 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
GTF3C5 Q9Y5Q8 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
GTF3C5 Q9Y5Q8 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
GTF3C5 Q9Y5Q8 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
GTF3C5 Q9Y5Q8 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05906 GTF3C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05907 GTF3C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown