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SLC25A10 - solute carrier family 25 member 10 Gene

Also Known as DIC; MTDPS19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1468

About SLC25A10

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,712,284-81,721,012 (from NCBI)

This gene has 8 transcripts (splice variants), 237 orthologues, 49 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 33.1), liver (RPKM 15.3) and 20 other tissues.

Summary

This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and Other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

SLC25A10 Products (3)

mRNA	Protein	Name
NM_001270888.2	NP_001257817.1	mitochondrial dicarboxylate carrier isoform 1
NM_001270953.2	NP_001257882.1	mitochondrial dicarboxylate carrier isoform 3
NM_012140.5	NP_036272.2	mitochondrial dicarboxylate carrier isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables dicarboxylic acid transmembrane transporter activity	EXP EXP: Inferred from Experiment	29211846	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19060904	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A10 Protein Structure

Mito_carr

0
100
200
287 a.a.

Protein Preferred Names	Protein Names
mitochondrial dicarboxylate carrier	dicarboxylate ion carrier

SLC25A10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC25A10	Q9UBX3	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	SLC25A10	Q9UBX3	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	SLC25A10	Q9UBX3	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	SLC25A10	Q9UBX3	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	SLC25A10	Q9UBX3	MDFI	Homo sapiens	Q99750	Y2H	21516116
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mitochondrial Dna Depletion Syndrome 19	MTDPS19
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Mitochondrial Dna Depletion Syndrome	Mtdna Depletion Syndrome
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13090	SLC25A10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC25A10	VGNC	VGNC:107277
Felis catus	SLC25A10	VGNC	VGNC:99452
Mus musculus	SLC25A10	MGD	MGI:1353497
Rattus norvegicus	SLC25A10	RGD	RGD:621430
Others	SLC25A10	NCBI