SLC25A10 - solute carrier family 25 member 10 Gene

Homo sapiens

Also known as DIC; MTDPS19

Gene ID: 1468 | Gene type: protein coding

About SLC25A10

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,712,284-81,721,012 (from NCBI)

This gene has 8 transcripts (splice variants), 237 orthologues, 49 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 33.1), liver (RPKM 15.3) and 20 other tissues.

Summary

This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

SLC25A10 Products(3)

mRNA	Protein	Name
NM_001270888.2	NP_001257817.1	mitochondrial dicarboxylate carrier isoform 1
NM_001270953.2	NP_001257882.1	mitochondrial dicarboxylate carrier isoform 3
NM_012140.5	NP_036272.2	mitochondrial dicarboxylate carrier isoform 2

SLC25A10 Protein Structure

Mito_carr

0
100
200
287 a.a.

Protein Preferred Names

Protein Names

mitochondrial dicarboxylate carrier

dicarboxylate ion carrier

Related Diseases

Diseases

Alias

Mitochondrial Dna Depletion Syndrome 19

MTDPS19

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13090	SLC25A10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC25A10	VGNC	VGNC:107277
Felis catus	SLC25A10	VGNC	VGNC:99452
Mus musculus	SLC25A10	MGD	MGI:1353497
Rattus norvegicus	SLC25A10	RGD	RGD:621430

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