ALDH3B1 - aldehyde dehydrogenase 3 family member B1 Gene

Also Known as ALDH4; ALDH7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221

About ALDH3B1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,008,547-68,029,276 (from NCBI)

This gene has 9 transcripts (splice variants), 355 orthologues and 17 paralogues. Broad expression in lung (RPKM 26.2), bone marrow (RPKM 14.3) and 17 other tissues.

Summary

This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

ALDH3B1 Products (5)

mRNA Protein Name
NM_000694.4 NP_000685.1 aldehyde dehydrogenase family 3 member B1 isoform a
NM_001030010.3 NP_001025181.1 aldehyde dehydrogenase family 3 member B1 isoform b
NM_001161473.3 NP_001154945.1 aldehyde dehydrogenase family 3 member B1 isoform a
NM_001290058.2 NP_001276987.1 aldehyde dehydrogenase family 3 member B1 isoform c
NM_001290059.2 NP_001276988.1 aldehyde dehydrogenase family 3 member B1 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aldehyde dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
20699116 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within aldehyde catabolic process IDA
IDA: Inferred from direct assay
20699116 GOA
acts upstream of or within cellular response to oxidative stress IDA
IDA: Inferred from direct assay
20699116 GOA
acts upstream of or within response to oxidative stress IDA
IDA: Inferred from direct assay
20699116 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20699116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH3B1 Protein Structure

Aldedh

Aldedh: Aldehyde dehydrogenase family (52 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase family 3 member B1

  • aldehyde dehydrogenase 3B1

ALDH3B1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALDH3B1 P43353 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
ALDH3B1 P43353 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
ALDH3B1 P43353 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra
ALDH3B1 P43353 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
ALDH3B1 P43353 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra
ALDH3B1 P43353 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
ALDH3B1 P43353 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
ALDH3B1 P43353 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRTAP12-3 Homo sapiens P60328
Validated Y2H
32296183
Intra
ALDH3B1 P43353 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
ALDH3B1 P43353 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
ALDH3B1 P43353 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
ALDH3B1 P43353 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
ALDH3B1 P43353 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
ALDH3B1 P43353 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
ALDH3B1 P43353 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
ALDH3B1 P43353 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Paranoid Schizophrenia

  • Chronic Paranoid Schizophrenia

  • Paranoid Type Schizophrenia

  • Paranoid Type Schizophrenia Subchronic State

  • Paraphrenia - Late

  • Paraphrenic Schizophrenia

  • Schizophrenia, Paranoid
Sjogren-Larsson Syndrome

  • Sjögren-Larsson Syndrome

  • SLS

  • Faldh Deficiency

  • Fatty Aldehyde Dehydrogenase Deficiency

  • Fatty Acid Alcohol Oxidoreductase Deficiency

  • Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia

  • Sjogren Larsson Syndrome

  • Fatty Alcohol:Nad+ Oxidoreductase Deficiency

  • Sjogren-Larsson'S Syndrome

  • Fadh Deficiency

  • Fao Deficiency

  • Congenital Icthyosis Mental Retardation Spasticity Syndrome

  • Ichthyosis Oligophrenia Syndrome

  • Sjoegren-Larsson Syndrome
Paraneoplastic Polyneuropathy
Epilepsy, Pyridoxine-Dependent

  • Pyridoxine-Dependent Epilepsy

  • PDE

  • Pyridoxine Dependency With Seizures

  • Vitamin B6-Dependent Seizures

  • EPD

  • Aasa Dehydrogenase Deficiency

  • Antiquitin Deficiency

  • Pyridoxine Dependency

  • Glutamate Decarboxylase Deficiency

  • Pyridoxine-Dependent Seizures

  • Deficiency Of Glutamate Decarboxylase
Hyperprolinemia

  • Proline Oxidase Deficiency

  • Hyperprolinemia Type 1

  • Proline Hydrogenase Deficiency

  • Prolinemia

  • Pyrroline Carboxylate Dehydrogenase Deficiency

  • Pyrroline-5-Carboxylate Dehydrogenase Deficiency

  • Proline Dehydrogenase Deficiency

  • Hyperprolinemia Type 2
Succinic Semialdehyde Dehydrogenase Deficiency

  • 4-Hydroxybutyric Aciduria

  • Ssadh Deficiency

  • Gamma-Hydroxybutyric Aciduria

  • Gaba Metabolic Defect

  • SSADHD

  • Ssadh

  • Succinate-Semialdehyde Dehydrogenase Deficiency

  • Gamma-Hydroxybutyricaciduria

  • 4-Hydroxybutyricaciduria

  • Gamma-Hydroxybutyric Acidemia

  • Succinate Semialdehyde Dehydrogenase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00575 ALDH3B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21982 Aldh3b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28499 Aldh3b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ALDH3B1 VGNC VGNC:56255
Macaca mulatta ALDH3B1 VGNC VGNC:69789
Mus musculus ALDH3B1 MGD MGI:1914939
Rattus norvegicus ALDH3B1 RGD RGD:1359546
Canis familiaris ALDH3B1 VGNC VGNC:51840
Others ALDH3B1 NCBI