ARSI - arylsulfatase family member I Gene

Also Known as ASI; SPG66

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340075

About ARSI

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,296,343-150,302,905 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues, 16 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 1.9), placenta (RPKM 1.8) and 20 other tissues.

Summary

This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]

ARSI Products (1)

mRNA Protein Name
NM_001012301.4 NP_001012301.1 arylsulfatase I precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARSI Protein Structure

Sulfatase

Sulfatase: Sulfatase (47 - 359)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 569 a.a.
Protein Preferred Names Protein Names

arylsulfatase I

ARSI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARSI Q5FYB1 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Autosomal Recessive Spastic Paraplegia Type 66

  • Spg66
Spastic Paraplegia 63, Autosomal Recessive

  • SPG63

  • Hereditary Spastic Paraplegia 63

  • Spastic Paraplegia 63

  • Autosomal Recessive Spastic Paraplegia 63

  • Autosomal Recessive Spastic Paraplegia Type 63

  • Paraplegia, Spastic, Type 63, Autosomal Recessive
Noonan Syndrome 8

  • NS8

  • Noonan Syndrome, Type 8
Spastic Paraplegia 78, Autosomal Recessive

  • SPG78

  • Autosomal Recessive Spastic Paraplegia Type 78

  • Hereditary Spastic Paraplegia 78

  • Spastic Paraplegia 78 Autosomal Recessive

  • Doid:0112348
Gastric Dilatation

  • Stomach Dilatation
Alternating Exotropia

  • Exotropia
Motor Neuron Disease

  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01040 ARSI Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARSI MGD MGI:2670959
Rattus norvegicus ARSI RGD RGD:1310242
Canis familiaris ARSI VGNC VGNC:38144
Macaca mulatta ARSI VGNC VGNC:69937
Bos taurus ARSI VGNC VGNC:26177
Felis catus ARSI VGNC VGNC:59948
Others ARSI NCBI