USP21 - ubiquitin specific peptidase 21 Gene

Also Known as USP16; USP23

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27005

About USP21

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,159,500-161,165,723 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 71 paralogues. Ubiquitous expression in ovary (RPKM 11.4), testis (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

USP21 Products (4)

mRNA	Protein	Name
NM_001014443.3	NP_001014443.1	ubiquitin carboxyl-terminal hydrolase 21 isoform c
NM_001319847.2	NP_001306776.1	ubiquitin carboxyl-terminal hydrolase 21 isoform a
NM_001319848.2	NP_001306777.1	ubiquitin carboxyl-terminal hydrolase 21 isoform b
NM_012475.5	NP_036607.3	ubiquitin carboxyl-terminal hydrolase 21 isoform c

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	10799498	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	26100909	GOA
enables cysteine-type peptidase activity	IMP IMP: Inferred from mutant phenotype	10799498	GOA
enables deNEDDylase activity	IDA IDA: Inferred from direct assay	10799498	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	32011234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP21 Protein Structure

UCH

0
100
200
300
400
500
565 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 21	NEDD8-specific protease

USP21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	USP21	Q9UK80	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	USP21	Q9UK80	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	USP21	Q9UK80	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	USP21	Q9UK80	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	USP21	Q9UK80	CPSF6	Homo sapiens	Q16630-2	Y2H Prey Pooling	32296183
Intra	USP21	Q9UK80	CPSF6	Homo sapiens	Q16630-2	Y2H Array	32296183
Intra	USP21	Q9UK80	HOXC10	Homo sapiens	Q9NYD6	Y2H Prey Pooling	32296183
Intra	USP21	Q9UK80	HOXC10	Homo sapiens	Q9NYD6	Y2H Array	32296183
Intra	USP21	Q9UK80	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	32296183
Intra	USP21	Q9UK80	KCTD9	Homo sapiens	Q7L273	Y2H Array	32296183
Intra	USP21	Q9UK80	UCHL1	Homo sapiens	P09936	Anti Tag CoIP	19615732
Intra	USP21	Q9UK80	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	USP21	Q9UK80	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13453	BAY 11-7082	Inhibitor	99.98%	Unkown
HY-153045	BAY-805	Inhibitor	99.89%	Unkown
HY-153045A	BAY-728		99.92%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP21	VGNC	VGNC:97680
Mus musculus	USP21	MGD	MGI:1353665
Macaca mulatta	USP21	VGNC	VGNC:78741
Canis familiaris	USP21	VGNC	VGNC:53133
Bos taurus	USP21	VGNC	VGNC:52843
Rattus norvegicus	USP21	RGD	RGD:1588822
Others	USP21	NCBI