2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. BAY-805

BAY-805 

Cat. No.: HY-153045
Handling Instructions

BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes.

For research use only. We do not sell to patients.

BAY-805 Chemical Structure

BAY-805 Chemical Structure

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Description

BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes[1].

IC50 & Target

USP21[1]
In Vitro

BAY-805 inhibits the activity of hUSP21 HTRF and hUSP21 Ub-Rhod with IC50 values of 6 nM and 2 nM, respectively[1].
BAY-805 (10 µM) induces the NF-κB activation with an EC50 value of 17 nM[1].
BAY-805 (10 µM and 50 µM) significantly inhibits the activity of USP21 and also shows weak influence on USP22 and USP10[1].
BAY-805 (0.0001-1000000 nM) selectively inhibits the activity of USP21[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

507.57

Formula

C24H28F3N5O2S
SMILES

O=C([[email protected]@H](CC(C)C)NC(C1(C(F)(F)F)CCCCC1)=O)NC2=NN=C(CC3=CC=C(C#N)C=C3)S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

BAY-805BAY805BAY 805DeubiquitinaseDUBsNF-κBDUBUSPInhibitorinhibitorinhibit

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