2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. BAY-805

BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes.

For research use only. We do not sell to patients.

BAY-805 Chemical Structure

BAY-805 Chemical Structure

CAS No. : 2925481-88-3

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Based on 1 publication(s) in Google Scholar

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BAY-805 Related Antibodies

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Description

BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes[1].

IC50 & Target

USP21[1]
In Vitro

BAY-805 inhibits the activity of hUSP21 HTRF and hUSP21 Ub-Rhod with IC50 values of 6 nM and 2 nM, respectively[1].
BAY-805 (10 µM) induces the NF-κB activation with an EC50 value of 17 nM[1].
BAY-805 (10 µM and 50 µM) significantly inhibits the activity of USP21 and also shows weak influence on USP22 and USP10[1].
BAY-805 (0.0001-1000000 nM) selectively inhibits the activity of USP21[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-805 Related Antibodies
Molecular Weight

507.57

Formula

C24H28F3N5O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](CC(C)C)NC(C1(C(F)(F)F)CCCCC1)=O)NC2=NN=C(CC3=CC=C(C#N)C=C3)S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (394.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9702 mL 9.8509 mL 19.7017 mL
5 mM 0.3940 mL 1.9702 mL 3.9403 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9702 mL 9.8509 mL 19.7017 mL 49.2543 mL
5 mM 0.3940 mL 1.9702 mL 3.9403 mL 9.8509 mL
10 mM 0.1970 mL 0.9851 mL 1.9702 mL 4.9254 mL
15 mM 0.1313 mL 0.6567 mL 1.3134 mL 3.2836 mL
20 mM 0.0985 mL 0.4925 mL 0.9851 mL 2.4627 mL
25 mM 0.0788 mL 0.3940 mL 0.7881 mL 1.9702 mL
30 mM 0.0657 mL 0.3284 mL 0.6567 mL 1.6418 mL
40 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2314 mL
50 mM 0.0394 mL 0.1970 mL 0.3940 mL 0.9851 mL
60 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8209 mL
80 mM 0.0246 mL 0.1231 mL 0.2463 mL 0.6157 mL
100 mM 0.0197 mL 0.0985 mL 0.1970 mL 0.4925 mL
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BAY-805 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-8052925481-88-3BAY805BAY 805DeubiquitinaseDUBsNF-κBDUBUSPInhibitorinhibitorinhibit

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