HOXC10 - homeobox C10 Gene

Also Known as HOX3I

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3226

About HOXC10

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,985,146-53,990,279 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 42 paralogues. Biased expression in kidney (RPKM 15.8), skin (RPKM 3.7) and 5 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]

HOXC10 Products (1)

mRNA Protein Name
NM_017409.4 NP_059105.2 homeobox protein Hox-C10

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10835276 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10835276 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28186086 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10835276 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXC10 Protein Structure

Homeobox

Homeobox: Homeobox domain (269 - 325)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-C10

  • homeo box C10

HOXC10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HOXC10 Q9NYD6 USP21 Homo sapiens Q9UK80
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06314 HOXC10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HOXC10 MGD MGI:96192
Canis familiaris HOXC10 VGNC VGNC:41756
Felis catus HOXC10 VGNC VGNC:67625
Macaca mulatta HOXC10 VGNC VGNC:73506
Bos taurus HOXC10 VGNC VGNC:56206
Rattus norvegicus HOXC10 RGD RGD:1307250
Others HOXC10 NCBI