TCTA - T cell leukemia translocation altered Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6988

About TCTA

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,412,423-49,416,476 (from NCBI)

This gene has 6 transcripts (splice variants) and 174 orthologues. Ubiquitous expression in thyroid (RPKM 27.1), kidney (RPKM 21.0) and 25 other tissues.

Summary

Involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TCTA Products (1)

mRNA	Protein	Name
NM_022171.3	NP_071503.1	T-cell leukemia translocation-altered gene protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	19560569	GOA
involved in osteoclast fusion	IDA IDA: Inferred from direct assay	19560569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCTA Protein Structure

T_cell_tran_alt

0
103 a.a.

Protein Preferred Names	Protein Names
T-cell leukemia translocation-altered gene protein	T-cell leukemia translocation-associated gene protein

TCTA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TCTA	P57738	SLC35A1	Homo sapiens	P78382	Validated Y2H	32296183
Intra	TCTA	P57738	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	TCTA	P57738	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Cataract 34, Multiple Types	Cataract, Autosomal Recessive Congenital 3 Cataract 34 Multiple Types CTRCT34 Catc3 Cataract 34, Multiple Types, With Or Without Microcornea Autosomal Recessive Congenital Cataract 3 Cataract 34 Multiple Types With Or Without Microcornea Cataract, Multiple Types, Type 34
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-142118	Trabedersen	Inhibitor	91.24%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14325	TCTA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TCTA	RGD	RGD:1359333
Mus musculus	TCTA	MGD	MGI:1918829
Others	TCTA	NCBI