2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Trabedersen

Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Trabedersen sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

DNA, d(P-thio)(C-G-G-C-A-T-G-T-C-T-A-T-T-T-T-G-T-A)

Trabedersen Chemical Structure

CAS No. : 925681-61-4

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Trabedersen Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon[1][2].

In Vitro

Trabedersen (1-80 μM; 7 days) reduces TGF-β2 secretion in human pancreatic cancer cell line Hup-T3 with an IC50 in the low μM range, clearly inhibits cell proliferation, and completely blocks migration of pancreatic cancer cells[2].
Trabedersen reverses TGF-β2-mediated immunosuppression of pancreatic cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trabedersen Related Antibodies

Cell Proliferation Assay[2]

Cell Line: Hup-T3 cells
Concentration: 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM, 60 μM, 80 μM
Incubation Time: 7 days
Result: Inhibited cell proliferation, and completely blocked migration of pancreatic cancer cells.
In Vivo

Trabedersen (initial loading dose of 50 mg/kg bodyweight followed by 16 mg/kg three times a week; i.p.) treatment significantly reduces tumor growth, lymph node metastasis and angiogenesis in an orthotopic mouse model of metastatic pancreatic cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male athymic nude mice (BALB⁄Cnu ⁄nu) bearing human pancreatic cancer cells[2].
Dosage: Initial loading dose of 50 mg/kg bodyweight followed by 16 mg/kg three times a week.
Administration: Intraperitoneal (i.p.) injection; three times a week; for 27 days
Result: Significantly reduced tumor growth, lymph node metastasis and angiogenesis.
Clinical Trial
Molecular Weight

5768.70

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

DNA, d(P-thio)(C-G-G-C-A-T-G-T-C-T-A-T-T-T-T-G-T-A)
SMILES

[Trabedersen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (17.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1733 mL 0.8667 mL 1.7335 mL
5 mM 0.0347 mL 0.1733 mL 0.3467 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
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V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.1733 mL 0.8667 mL 1.7335 mL 4.3337 mL
5 mM 0.0347 mL 0.1733 mL 0.3467 mL 0.8667 mL
10 mM 0.0173 mL 0.0867 mL 0.1733 mL 0.4334 mL
15 mM 0.0116 mL 0.0578 mL 0.1156 mL 0.2889 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Trabedersen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trabedersen925681-61-4AP 12009AP12009AP-12009TGF-beta/SmadTransforming growth factor betaantisense oligodeoxynucleotideTGF-β2anticancer activitysolid tumorsInhibitorinhibitorinhibit

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