APCDD1L - APC down-regulated 1 like Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 164284

About APCDD1L

This gene has 3 transcripts (splice variants), 174 orthologues and 1 paralogue. Biased expression in salivary gland (RPKM 5.3), kidney (RPKM 1.7) and 6 other tissues.

Summary

Predicted to enable Wnt-protein binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

APCDD1L Products (2)

mRNA Protein Name
NM_001304787.2 NP_001291716.1 protein APCDD1-like isoform 2
NM_153360.3 NP_699191.1 protein APCDD1-like isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APCDD1L Protein Structure

APCDDC

APCDDC: Adenomatosis polyposis coli down-regulated 1 (41 - 271)

APCDDC

APCDDC: Adenomatosis polyposis coli down-regulated 1 (279 - 454)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

protein APCDD1-like

  • adenomatosis polyposis coli down-regulated 1 like

APCDD1L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
APCDD1L Q8NCL9 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
APCDD1L Q8NCL9 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
APCDD1L Q8NCL9 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 103

  • DFNB103

  • Autosomal Recessive Nonsyndromic Deafness 103

  • Autosomal Recessive Deafness 103

  • Deafness, Autosomal Recessive, 103

  • Deafness, Autosomal Recessive, Type 103
Amelogenesis Imperfecta, Type Ie

  • Aih1

  • Amelogenesis Imperfecta Type 1e

  • AI1E

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

  • Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

  • Enamel Hypoplasia, X-Linked

  • Amelogenesis Imperfecta Type Ie

  • Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

  • Enamel Hypoplasia X-Linked

  • Amelogenesis Imperfecta, X-Linked 1

  • Amelogenesis Imperfecta, Type 1e

  • Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

  • X-Linked Amelogenesis Imperfecta 1

  • X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

  • X-Linked Enamel Hypoplasia

  • Amelogenesis Imperfecta X-Linked 1

  • Amelogenesis Imperfecta 1e

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

  • Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

  • Xai

  • X-Linked Amelogenesis Imperfecta

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00812 APCDD1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27743 Apcdd1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris APCDD1L VGNC VGNC:37981
Rattus norvegicus APCDD1L RGD RGD:1562045
Macaca mulatta APCDD1L VGNC VGNC:84543
Bos taurus APCDD1L VGNC VGNC:26008
Felis catus APCDD1L VGNC VGNC:59847
Others APCDD1L NCBI