SYNJ2BP - synaptojanin 2 binding protein Gene

Also Known as ARIP2; OMP25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55333

About SYNJ2BP

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,366,499-70,417,090 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 23.3), duodenum (RPKM 20.4) and 24 other tissues.

Summary

Predicted to enable type II activin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of sprouting angiogenesis; and regulation of signal transduction. Located in mitochondrion. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYNJ2BP Products (1)

mRNA Protein Name
NM_018373.3 NP_060843.2 synaptojanin-2-binding protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24025447 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
24025447 GOA
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
24025447 GOA
involved in negative regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
24025447 GOA
involved in negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
24025447 GOA
involved in negative regulation of sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
24025447 GOA
involved in regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
24025447 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
32973005 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
18845145 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNJ2BP Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (14 - 97)

  • 0
  • 100
  • 145 a.a.
Protein Preferred Names Protein Names

synaptojanin-2-binding protein

  • activin receptor interacting protein 5

SYNJ2BP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYNJ2BP P57105 THEM5 Homo sapiens Q8N1Q8
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 THEM5 Homo sapiens Q8N1Q8
Validated Y2H
32296183
Intra
SYNJ2BP P57105 THEM5 Homo sapiens Q8N1Q8
Y2H Array
32296183
Intra
SYNJ2BP P57105 ELOVL7 Homo sapiens A1L3X0
Y2H Array
32296183
Intra
SYNJ2BP P57105 ELOVL7 Homo sapiens A1L3X0
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra
SYNJ2BP P57105 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
SYNJ2BP P57105 MEDAG Homo sapiens Q5VYS4
Validated Y2H
32296183
Intra
SYNJ2BP P57105 MEDAG Homo sapiens Q5VYS4
Y2H Array
32296183
Intra
SYNJ2BP P57105 MEDAG Homo sapiens Q5VYS4
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 ELOVL5 Homo sapiens Q9NYP7
Validated Y2H
32296183
Intra
SYNJ2BP P57105 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
SYNJ2BP P57105 DLL4 Homo sapiens Q9NR61
Anti Bait CoIP
24025447
Intra
SYNJ2BP P57105 DLL4 Homo sapiens Q9NR61
Lumier
24025447
Intra
SYNJ2BP P57105 DLL4 Homo sapiens Q9NR61
Confocal
24025447
Intra
SYNJ2BP P57105 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
SYNJ2BP P57105 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
SYNJ2BP P57105 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
SYNJ2BP P57105 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SYNJ2BP P57105 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra
SYNJ2BP P57105 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra
SYNJ2BP P57105 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
SYNJ2BP P57105 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
SYNJ2BP P57105 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
SYNJ2BP P57105 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SYNJ2BP P57105 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
SYNJ2BP P57105 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
SYNJ2BP P57105 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
SYNJ2BP P57105 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
SYNJ2BP P57105 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
SYNJ2BP P57105 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
SYNJ2BP P57105 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 TMEM101 Homo sapiens Q96IK0
Y2H Array
32296183
Intra
SYNJ2BP P57105 TMEM101 Homo sapiens Q96IK0
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 TMEM101 Homo sapiens Q96IK0
Validated Y2H
32296183
Intra
SYNJ2BP P57105 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SYNJ2BP P57105 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SYNJ2BP P57105 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra
SYNJ2BP P57105 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra
SYNJ2BP P57105 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra
SYNJ2BP P57105 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
SYNJ2BP P57105 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
SYNJ2BP P57105 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SYNJ2BP P57105 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
SYNJ2BP P57105 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
SYNJ2BP P57105 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
SYNJ2BP P57105 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SYNJ2BP P57105 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
SYNJ2BP P57105 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
SYNJ2BP P57105 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

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  • Mediterranean Fever

  • Malta Fever

  • Undulant Fever

  • Gibraltar Fever

  • Bang'S Disease

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Colorectal Cancer, Hereditary Nonpolyposis, Type 7

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  • Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7
Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities

  • IDDSSBA
Trench Fever

  • His-Werner Disease

  • Quintan Fever

  • Shin Bone Fever

  • Wolhynian Fever

  • Tibialgic Fever

  • Bartonellosis Due To Bartonella Quintana Infection

  • Febris Quintata

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  • Fever Due To Rickettsia Quintana

  • Febris Quintana

  • Fever Due To Bartonella Quintana

  • Fever Due To Rochalimaea Quintana

  • Meuse Fever
Bacillary Angiomatosis

  • Angiomatosis, Bacillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141659 CMPD-39 99.74% Unkown
HY-141659A (R)-CMPD-39 99.78% Unkown
HY-RS14095 SYNJ2BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SYNJ2BP RGD RGD:69400
Mus musculus SYNJ2BP MGD MGI:1344347
Others SYNJ2BP NCBI