THEM5 - thioesterase superfamily member 5 Gene

Also Known as ACOT15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 284486

About THEM5

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,847,101-151,853,712 (from NCBI)

This gene has 2 transcripts (splice variants), 88 orthologues and 1 paralogue. Biased expression in skin (RPKM 49.5) and brain (RPKM 1.6).

Summary

Enables palmitoyl-CoA hydrolase activity. Involved in long-chain fatty-acyl-CoA metabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

THEM5 Products (1)

mRNA Protein Name
NM_182578.4 NP_872384.2 acyl-coenzyme A thioesterase THEM5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
22586271 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in long-chain fatty-acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
22586271 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
22586271 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THEM5 Protein Structure

4HBT

4HBT: Thioesterase superfamily (155 - 228)

  • 0
  • 100
  • 200
  • 247 a.a.
Protein Preferred Names Protein Names

acyl-coenzyme A thioesterase THEM5

  • acyl-CoA thioesterase THEM5

THEM5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THEM5 Q8N1Q8 MAGEA11 Homo sapiens P43364-2
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polyneuropathy Due To Drug
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14486 THEM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus THEM5 RGD RGD:1562059
Canis familiaris THEM5 VGNC VGNC:47342
Mus musculus THEM5 MGD MGI:1913448
Felis catus THEM5 VGNC VGNC:66160
Bos taurus THEM5 VGNC VGNC:50123