RAP2A - RAP2A, member of RAS oncogene family Gene

Homo sapiens

Also known as KREV; RAP2; K-REV; RbBP-30

Gene ID: 5911 | Gene type: protein coding

About RAP2A

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:97,434,169-97,469,128 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 41.0), placenta (RPKM 14.5) and 23 other tissues.

Summary

Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including actin Cytoskeleton reorganization; microvillus assembly; and positive regulation of protein autophosphorylation. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAP2A Products(1)

mRNA	Protein	Name
NM_021033.7	NP_066361.1	ras-related protein Rap-2a

RAP2A Protein Structure

Ras

0
100
183 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rap-2a

RAP2, member of RAS oncogene family (K-rev)

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Sporadic Breast Cancer

Sporadic Breast Carcinoma

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11657	RAP2A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAP2A	VGNC	VGNC:33719
Mus musculus	RAP2A	MGD	MGI:97855
Felis catus	RAP2A	VGNC	VGNC:102303
Rattus norvegicus	RAP2A	RGD	RGD:620590
Canis familiaris	RAP2A	VGNC	VGNC:45344
Macaca mulatta	RAP2A	VGNC	VGNC:106288

Name
Email *

	Sorry, but the email address you supplied was invalid.