Claudin 7 Antibody (YA5490)
(Synonyms: CEPTR L2; CEPTRL 2; CEPTRL2; Claudin 1; Claudin 7; Claudin 9; Claudin-7; Claudin1; Claudin7; Claudin9; CLD7_HUMAN; CLDN 7; CLDN-7; CLDN7; Clostridium perfringens enterotoxin receptor like 2; CPETR L2; CPETRL 2; CPETRL2; Hs.84359)Claudin 7 Antibody (YA5490) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin 7.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
Claudin 7 Antibody (YA5490) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin 7.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22 kDa
Synthesized peptide derived from human Claudin 7 AA range: 100-211
Protein G
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Claudin 7 plays a major role in tight junction-specific obliteration of the intercellular space
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Cell junction, tight junction
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Expression
Tissue_specificity:This gene is expressed in the kidneys, lungs, and prostate. Isoform 1 appears to be dominant, except in some normal prostate samples where isoform 2 is predominant. In breast cancer, including ductal carcinoma in situ (DCIS) , lobular carcinoma in situ (LCIS) , and invasive ductal carcinoma (IDC) (protein level) , and in various cancer cell lines, this gene expression is downregulated. Loss of expression is associated with histological grade, primarily occurring in high-grade lesions.
Induction:By androgens -
Isoforms & Post-Translational Modification
O95471 has 2 isomers: O95471-1: 22418 Da (predicted); O95471-2: 16837 Da (predicted).
Phosphorylated -
Subunit
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM (PubMed:16054130). Does not interact with CD81 (PubMed:20375010)
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SwissProt ID
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Synonyms
CEPTR L2; CEPTRL 2; CEPTRL2; Claudin 1; Claudin 7; Claudin 9; Claudin-7; Claudin1; Claudin7; Claudin9; CLD7_HUMAN; CLDN 7; CLDN-7; CLDN7; Clostridium perfringens enterotoxin receptor like 2; CPETR L2; CPETRL 2; CPETRL2; Hs.84359
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