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SCARF1 - scavenger receptor class F member 1 Gene

Also Known as SREC; SREC1; SREC-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8578

About SCARF1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,633,858-1,645,732 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 190 orthologues and 3 paralogues. Broad expression in spleen (RPKM 18.4), lung (RPKM 9.9) and 22 other tissues.

Summary

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

SCARF1 Products (2)

mRNA	Protein	Name
NM_003693.4	NP_003684.2	scavenger receptor class F member 1 isoform 1 precursor
NM_145350.3	NP_663325.1	scavenger receptor class F member 1 isoform 3 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	9395444	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	9395444	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	9395444	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCARF1 Protein Structure

hEGF

Laminin_EGF

hEGF

0
200
400
600
830 a.a.

Protein Preferred Names	Protein Names
scavenger receptor class F member 1	acetyl LDL receptor

SCARF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCARF1	Q14162	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
Intra	SCARF1	Q14162	MRM3	Homo sapiens	Q9HC36	Y2H Array	32296183
Intra	SCARF1	Q14162	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	SCARF1	Q14162	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SCARF1	Q14162	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	SCARF1	Q14162	LCE1D	Homo sapiens	Q5T752	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	LCE1D	Homo sapiens	Q5T752	Validated Y2H	32296183
Intra	SCARF1	Q14162	LCE1D	Homo sapiens	Q5T752	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	SCARF1	Q14162	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	SCARF1	Q14162	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	SCARF1	Q14162	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SCARF1	Q14162	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SCARF1	Q14162	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SCARF1	Q14162	LHFPL2	Homo sapiens	Q6ZUX7	Validated Y2H	32296183
Intra	SCARF1	Q14162	LHFPL2	Homo sapiens	Q6ZUX7	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	LHFPL2	Homo sapiens	Q6ZUX7	Y2H Array	32296183
Intra	SCARF1	Q14162	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	SCARF1	Q14162	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	SCARF1	Q14162	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	SCARF1	Q14162	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SCARF1	Q14162	TGM1	Homo sapiens	P22735	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	TGM1	Homo sapiens	P22735	Validated Y2H	32296183
Intra	SCARF1	Q14162	TGM1	Homo sapiens	P22735	Y2H Array	32296183
Intra	SCARF1	Q14162	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	SCARF1	Q14162	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SCARF1	Q14162	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	SCARF1	Q14162	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	SCARF1	Q14162	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SCARF1	Q14162	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SCARF1	Q14162	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	SCARF1	Q14162	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	SCARF1	Q14162	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	SCARF1	Q14162	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acute Gonococcal Cervicitis	Gonococcal Cervicitis Acute Gonorrhea Of Cervix
Acute Cervicitis
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset	EMARDD Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia
Ophthalmia Neonatorum	Gonococcal Conjunctivitis Gonococcal Ophthalmia Neonatorum Neonatal Conjunctivitis
Van Den Ende-Gupta Syndrome	VDEGS Blepharophimosis, Arachnodactyly, And Congenital Contractures Marden-Walker-Like Syndrome Marden-Walker-Like Syndrome Without Psychomotor Retardation Marden Walker Like Syndrome Marden-Walker-Like Syndrome Without Psychmotor Retardation Van Den Ende Gupta Syndrome Marden Walker Like Syndrome Without Psychomotor Retardation Blepharophimosis Arachnodactyly And Congenital Contractures
Chromosome 17p13.3, Centromeric, Duplication Syndrome	Chromosome 17p13.3 Duplication Syndrome 17p13.3 Duplication Syndrome 17p13.3 Microduplication Syndrome Trisomy 17p13.3 Chromosome 17p13.3 Centromeric Duplication Syndrome Dup(17)(P13.3)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12490	SCARF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21926	Scarf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28442	Scarf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SCARF1	VGNC	VGNC:77027
Felis catus	SCARF1	VGNC	VGNC:99445
Bos taurus	SCARF1	VGNC	VGNC:34326
Mus musculus	SCARF1	MGD	MGI:2449455
Rattus norvegicus	SCARF1	RGD	RGD:1309330
Others	SCARF1	NCBI