CD53 Antibody (YA1115)
(Synonyms: CD53; MOX44; TSPAN25; Leukocyte surface antigen CD53; Cell surface glycoprotein CD53; Tetraspanin-25; Tspan-25; CD53)CD53 Antibody (YA1115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD53.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
IHC-P
-
Reactivity :
Human
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.95.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
CD53 Antibody (YA1115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD53.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 35-55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 24 kDa
A synthesized peptide derived from human CD53
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.95.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
CD53 is a Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells. Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling. Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates. Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression. Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment[1][2][3][4].
-
Subcellular Localization
Cell membrane; Cell junction; Membrane; Multi-pass membrane protein; Synapse
-
Expression
Tissue_specificity:B cells, monocytes, macrophages, neutrophils, single-positive (CD4 or CD8) thymocytes, and peripheral T cells -
Subunit
Interacts with SCIMP (PubMed:21930792). Interacts with CD45/PTPRC (PubMed:35767951). Interacts with IL7R (By similarity). Interacts with RBL2 and PPP2CA (By similarity)
-
SwissProt ID
-
Synonyms
CD53; MOX44; TSPAN25; Leukocyte surface antigen CD53; Cell surface glycoprotein CD53; Tetraspanin-25; Tspan-25; CD53
-
Research Field
Immunology
Documentation
Powered by Bioz
