GPR108 - G protein-coupled receptor 108 Gene

Also Known as LUSTR2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56927

About GPR108

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,729,914-6,737,580 (from NCBI)

This gene has 17 transcripts (splice variants), 188 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 21.4), duodenum (RPKM 17.0) and 25 other tissues.

Summary

Predicted to be involved in negative regulation of Toll-like Receptor signaling pathway. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

GPR108 Products (17)

mRNA Protein Name
NM_001080452.2 NP_001073921.1 protein GPR108 isoform 1 precursor
NM_001394714.1 NP_001381643.1 protein GPR108 isoform 2
NM_001394715.1 NP_001381644.1 protein GPR108 isoform 2
NM_001394716.1 NP_001381645.1 protein GPR108 isoform 2
NM_001394717.1 NP_001381646.1 protein GPR108 isoform 3 precursor
NM_001394718.1 NP_001381647.1 protein GPR108 isoform 4 precursor
NM_001394719.1 NP_001381648.1 protein GPR108 isoform 5 precursor
NM_001394720.1 NP_001381649.1 protein GPR108 isoform 6
NM_001394721.1 NP_001381650.1 protein GPR108 isoform 7
NM_001394722.1 NP_001381651.1 protein GPR108 isoform 8
NM_001394723.1 NP_001381652.1 protein GPR108 isoform 9 precursor
NM_001394724.1 NP_001381653.1 protein GPR108 isoform 10
NM_001394725.1 NP_001381654.1 protein GPR108 isoform 11
NM_001394726.1 NP_001381655.1 protein GPR108 isoform 11
NM_001394727.1 NP_001381656.1 protein GPR108 isoform 12
NM_001394728.1 NP_001381657.1 protein GPR108 isoform 13
NM_020171.2 NP_064556.1 protein GPR108 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
32280726 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
31784416 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR108 Protein Structure

Lung_7-TM_R

Lung_7-TM_R: Lung seven transmembrane receptor (215 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 543 a.a.
Protein Preferred Names Protein Names

protein GPR108

  • lung seven transmembrane receptor 2

GPR108 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR108 Q9NPR9 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
GPR108 Q9NPR9 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
GPR108 Q9NPR9 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
GPR108 Q9NPR9 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
GPR108 Q9NPR9 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
GPR108 Q9NPR9 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
GPR108 Q9NPR9 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
GPR108 Q9NPR9 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
GPR108 Q9NPR9 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
GPR108 Q9NPR9 MTERF3 Homo sapiens Q96E29
Y2H Array
32296183
Intra
GPR108 Q9NPR9 MTERF3 Homo sapiens Q96E29
Y2H Prey Pooling
32296183
Intra
GPR108 Q9NPR9 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
GPR108 Q9NPR9 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Periosteal Chondrosarcoma

  • Juxtacortical Chondrosarcoma
Megalencephalic Leukoencephalopathy With Subcortical Cysts 1

  • Van Der Knaap Disease

  • Leukoencephalopathy With Swelling And Cysts

  • MLC1

  • Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts

  • Lvm

  • Vl

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1

  • Megalencephalic Leukoencephalopathy With Subcortical Cysts
Enchondromatosis, Multiple, Ollier Type

  • Ollier Disease

  • Enchondromatosis

  • Dyschondroplasia

  • Osteochondromatosis

  • Multiple Cartilaginous Enchondroses

  • Multiple Enchondromatosis

  • Enchondromatosis With Haemangiomata

  • Enchondromatosis, Multiple

  • Kast'S Syndrome

  • Ollier'S Syndrome

  • Enchondromatosis Multiple

  • ENCHOM

  • Maffucci Disease

  • Olliers Disease

  • Hereditary Multiple Exostoses

  • Chondromatosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05651 GPR108 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR108 VGNC VGNC:29545
Canis familiaris GPR108 VGNC VGNC:41393
Felis catus GPR108 VGNC VGNC:62671
Mus musculus GPR108 MGD MGI:1925558
Rattus norvegicus GPR108 RGD RGD:735149
Others GPR108 NCBI