2. Gene
  3. UCKL1 - uridine-cytidine kinase 1 like 1 Gene

UCKL1 - uridine-cytidine kinase 1 like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UCK1L; URKL1

Gene ID: 54963 | Gene type: protein coding

About UCKL1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,939,829-63,956,416 (from NCBI)

This gene has 7 transcripts (splice variants), 258 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 6.2), ovary (RPKM 4.9) and 25 other tissues.

Summary

The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

UCKL1 Products(10)

mRNA Protein Name
NM_001193379.2 NP_001180308.1 uridine-cytidine kinase-like 1 isoform 2
NM_001353475.2 NP_001340404.1 uridine-cytidine kinase-like 1 isoform 3
NM_001353476.2 NP_001340405.1 uridine-cytidine kinase-like 1 isoform 4
NM_001353477.2 NP_001340406.1 uridine-cytidine kinase-like 1 isoform 5
NM_001353478.2 NP_001340407.1 uridine-cytidine kinase-like 1 isoform 6
NM_001353479.2 NP_001340408.1 uridine-cytidine kinase-like 1 isoform 7
NM_001353480.2 NP_001340409.1 uridine-cytidine kinase-like 1 isoform 8
NM_001353481.2 NP_001340410.1 uridine-cytidine kinase-like 1 isoform 9
NM_001353482.2 NP_001340411.1 uridine-cytidine kinase-like 1 isoform 9
NM_017859.4 NP_060329.2 uridine-cytidine kinase-like 1 isoform 1

UCKL1 Protein Structure

PRK

PRK: Phosphoribulokinase / Uridine kinase family (101 - 286)

UPRTase

UPRTase: Uracil phosphoribosyltransferase (329 - 532)

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  • 548 a.a.
Protein Preferred Names Protein Names

uridine-cytidine kinase-like 1

UCK1-LIKE

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15405 UCKL1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UCKL1 VGNC VGNC:48106
Bos taurus UCKL1 VGNC VGNC:36636
Macaca mulatta UCKL1 VGNC VGNC:78992
Rattus norvegicus UCKL1 RGD RGD:1565465
Mus musculus UCKL1 MGD MGI:1915806