UCKL1 - uridine-cytidine kinase 1 like 1 Gene

Also Known as UCK1L; URKL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54963

About UCKL1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,939,829-63,956,416 (from NCBI)

This gene has 7 transcripts (splice variants), 258 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 6.2), ovary (RPKM 4.9) and 25 other tissues.

Summary

The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

UCKL1 Products (10)

mRNA Protein Name
NM_001193379.2 NP_001180308.1 uridine-cytidine kinase-like 1 isoform 2
NM_001353475.2 NP_001340404.1 uridine-cytidine kinase-like 1 isoform 3
NM_001353476.2 NP_001340405.1 uridine-cytidine kinase-like 1 isoform 4
NM_001353477.2 NP_001340406.1 uridine-cytidine kinase-like 1 isoform 5
NM_001353478.2 NP_001340407.1 uridine-cytidine kinase-like 1 isoform 6
NM_001353479.2 NP_001340408.1 uridine-cytidine kinase-like 1 isoform 7
NM_001353480.2 NP_001340409.1 uridine-cytidine kinase-like 1 isoform 8
NM_001353481.2 NP_001340410.1 uridine-cytidine kinase-like 1 isoform 9
NM_001353482.2 NP_001340411.1 uridine-cytidine kinase-like 1 isoform 9
NM_017859.4 NP_060329.2 uridine-cytidine kinase-like 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12199906 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCKL1 Protein Structure

PRK

PRK: Phosphoribulokinase / Uridine kinase family (101 - 286)

UPRTase

UPRTase: Uracil phosphoribosyltransferase (329 - 532)

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  • 548 a.a.
Protein Preferred Names Protein Names

uridine-cytidine kinase-like 1

  • UCK1-LIKE

UCKL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UCKL1 Q9NWZ5 RNF19B Homo sapiens Q6ZMZ0
Confocal
16709802
Intra
UCKL1 Q9NWZ5 RNF19B Homo sapiens Q6ZMZ0
Y2H
16709802
Intra
UCKL1 Q9NWZ5 RNF19B Homo sapiens Q6ZMZ0
Anti Bait CoIP
16709802
Cross
UCKL1 Q9NWZ5 EBNA3 Epstein-Barr virus P12977
Y2H
12199906
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15405 UCKL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UCKL1 VGNC VGNC:48106
Bos taurus UCKL1 VGNC VGNC:36636
Macaca mulatta UCKL1 VGNC VGNC:78992
Rattus norvegicus UCKL1 RGD RGD:1565465
Mus musculus UCKL1 MGD MGI:1915806
Others UCKL1 NCBI