TECR - trans-2,3-enoyl-CoA reductase Gene

Homo sapiens

Also known as SC2; TER; GPSN2; MRT14

Gene ID: 9524 | Gene type: protein coding

About TECR

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,527,726-14,565,980 (from NCBI)

This gene has 26 transcripts (splice variants), 268 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 95.3), skin (RPKM 93.5) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

TECR Products(2)

mRNA	Protein	Name
NM_001321170.1	NP_001308099.1	very-long-chain enoyl-CoA reductase isoform 2
NM_138501.6	NP_612510.1	very-long-chain enoyl-CoA reductase isoform 1

TECR Protein Structure

Steroid_dh

0
100
200
308 a.a.

Protein Preferred Names

Protein Names

very-long-chain enoyl-CoA reductase

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 14

MRT14	Mental Retardation, Autosomal Recessive 14
Autosomal Recessive Intellectual Developmental Disorder 14	Mental Retardation, Autosomal Recessive, Type 14

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Seborrheic Infantile Dermatitis

Cradle Cap	Infantile Seborrhoeic Dermatitis
Seborrhoea Capitis	Seborrhoeic Dermatitis Of Scalp
Seborrhoeic Eczema Of Scalp	Complement 5 Dysfunction
Generalized Seborrheic Dermatitis Of Infants	Infantile Seborrheic Dermatitis
Pityriasis Capitis	Seborrhea Capitis
Seborrhea Sicca	Dandruff
Complement Component 5 Deficiency	Seborrheic Dermatitis
Seborrheic Dermatitis Of Scalp	Scurfiness Of Scalp
Seborrheic Dermatitis Of Infancy	Infantile Seborrhoeic Eczema
Neonatal Seborrhoeic Dermatitis	Infantile Seborrhoeic Dermatitis Of The Scalp

Cataract 24

CTRCT24	Cataract 24, Anterior Polar
Cataract, Anterior Polar, 2	Ctaa2
Anterior Polar Cataract 2	Early-Onset Anterior Polar Cataract
Early-Onset Anterior Subcapsular Cataract	Anterior Polar Cataract 24
Cataract Anterior Polar	Cataract, Anterior Polar-2
Cataract, Anterior Polar

Tongue Carcinoma

Tongue Cancer	Malignant Neoplasm Of Tongue
Tongue Neoplasms	Tongue Neoplasm

Oral Mucosa Leukoplakia

Leukoplakia, Oral

Leukoplakia Of Buccal Mucosa

Spindle Cell Hemangioma

Sch	Spindle Cell Hemangioendothelioma

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14349	TECR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TECR	VGNC	VGNC:80732
Macaca mulatta	TECR	VGNC	VGNC:103877
Canis familiaris	TECR	VGNC	VGNC:47234
Rattus norvegicus	TECR	RGD	RGD:620376
Bos taurus	TECR	VGNC	VGNC:35730
Mus musculus	TECR	MGD	MGI:1915408