SLC39A13 - solute carrier family 39 member 13 Gene

Also Known as ZIP13; SCDEDS; EDSSPD3; LZT-Hs9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91252

About SLC39A13

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,407,276-47,416,500 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues, 1 paralogue and is associated with 4 phenotypes. Ubiquitous expression in placenta (RPKM 19.2), testis (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome. Alternate transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

SLC39A13 Products (3)

mRNA	Protein	Name
NM_001128225.3	NP_001121697.2	zinc transporter ZIP13 isoform a precursor
NM_001330245.2	NP_001317174.2	zinc transporter ZIP13 isoform c precursor
NM_152264.5	NP_689477.3	zinc transporter ZIP13 isoform b precursor

SLC39A13 Protein Structure

Zip

0
100
200
300
371 a.a.

Protein Preferred Names	Protein Names
zinc transporter ZIP13	LIV-1 subfamily of ZIP zinc transporter 9

SLC39A13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC39A13	Q96H72	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	SLC39A13	Q96H72	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	SLC39A13	Q96H72	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	SLC39A13	Q96H72	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	SLC39A13	Q96H72	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	SLC39A13	Q96H72	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	SLC39A13	Q96H72	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	SLC39A13	Q96H72	TCF4	Homo sapiens	P15884	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]
Hypermanganesemia With Dystonia 2	HMNDYT2 Dystonia-Parkinsonism-Hypermanganesemia Syndrome Hypermanganesemia With Dystonia, Type 2
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Ehlers-Danlos Syndrome, Hypermobility Type	Ehlers-Danlos Syndrome, Type 3 Ehlers-Danlos Syndrome, Type Iii EDSHMB Eds Iii Benign Hypermobility Syndrome Ehlers-Danlos Syndrome Hypermobility Type Eds3 Type Iii Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome Type 3 Es-D3
Hypermanganesemia With Dystonia	Familial Manganese-Induced Neurotoxicity Hmndyt
Hypermobility Syndrome	Benign Joint Hypermobility
Frontonasal Dysplasia 2	FND2 Frontonasal Dysplasia With Alopecia And Genital Anomaly Frontonasal Dysplasia-Alopecia-Genital Anomalies Syndrome Alx4-Related Fndag Craniofrontonasal Dysplasia With Alopecia And Hypogonadism Frontonasal Dysplasia Type 2 Frontonasal Dysplasia With Alopecia And Genital Abnomality Doid:0081046 Dysplasia, Frontonasal, Type 2
Collagen Disease	Collagen Diseases Collagen Disorder
Larsen-Like Syndrome B3gat3 Type	Larsen-Like Syndrome, B3gat3 Type Multiple Joint Dislocations-Short Stature-Craniofacial Dysmorphism-Congenital Heart Defects Syndrome Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Congenital Heart Defects Joint Dislocations, Multiple, Short Stature, Craniofacial Dysmorphism, Congenital Heart Defects
Radioulnar Synostosis	Radio-Ulnar Synostosis Type 1
Enophthalmos
Spondyloepimetaphyseal Dysplasia With Joint Laxity	Dysplasia, Spondyloepimetaphyseal, With Joint Laxity Semdjl Spondyloepimetaphyseal Dysplasia Joint Laxity Semd-Jl Semdjl1 Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 1 Spondyloepimetaphyseal Dysplasia With Joint Laxity, Beighton Type
Metal Metabolism Disorder	Metal Metabolism, Inborn Errors Inborn Metal Metabolism Disorder
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13232	SLC39A13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC39A13	VGNC	VGNC:56096
Macaca mulatta	SLC39A13	VGNC	VGNC:77538
Felis catus	SLC39A13	VGNC	VGNC:65357
Mus musculus	SLC39A13	MGD	MGI:1915677
Rattus norvegicus	SLC39A13	RGD	RGD:1304695
Bos taurus	SLC39A13	VGNC	VGNC:34861
Others	SLC39A13	NCBI