SLC9B2 - solute carrier family 9 member B2 Gene

Also Known as NHA2; NHE10; NHEDC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 133308

About SLC9B2

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:103,018,029-103,077,319 (from NCBI)

This gene has 11 transcripts (splice variants), 293 orthologues and 1 paralogue. Broad expression in brain (RPKM 4.9), liver (RPKM 4.7) and 21 other tissues.

Summary

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive Other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

SLC9B2 Products (12)

mRNA Protein Name
NM_001300754.2 NP_001287683.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001300756.2 NP_001287685.1 sodium/hydrogen exchanger 9B2 isoform 3
NM_001370199.1 NP_001357128.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_001370200.1 NP_001357129.1 sodium/hydrogen exchanger 9B2 isoform 5
NM_001370201.1 NP_001357130.1 sodium/hydrogen exchanger 9B2 isoform 1
NM_001370202.1 NP_001357131.1 sodium/hydrogen exchanger 9B2 isoform 1
NM_001370203.1 NP_001357132.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001370204.1 NP_001357133.1 sodium/hydrogen exchanger 9B2 isoform 2
NM_001370205.1 NP_001357134.1 sodium/hydrogen exchanger 9B2 isoform 3
NM_001370206.1 NP_001357135.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_001370207.1 NP_001357136.1 sodium/hydrogen exchanger 9B2 isoform 4
NM_178833.7 NP_849155.2 sodium/hydrogen exchanger 9B2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
28071645 GOA
enables lithium:proton antiporter activity IDA
IDA: Inferred from direct assay
36177733 GOA
enables lithium:proton antiporter activity IMP
IMP: Inferred from mutant phenotype
18000046 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sodium:proton antiporter activity EXP
EXP: Inferred from Experiment
28154142 GOA
enables sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
36177733 GOA
enables sodium:proton antiporter activity IMP
IMP: Inferred from mutant phenotype
18000046 GOA
Biological Process GO Annotation Evidence References Source
involved in lithium ion transport IDA
IDA: Inferred from direct assay
36177733 GOA
involved in sodium ion transport IDA
IDA: Inferred from direct assay
18508966 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
18508966 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18000046 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC9B2 Protein Structure

Na_H_Exchanger

Na_H_Exchanger: Sodium/hydrogen exchanger family (129 - 508)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 9B2

  • NHE domain-containing protein 2

SLC9B2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC9B2 Q86UD5 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
SLC9B2 Q86UD5 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13350 SLC9B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC9B2 RGD RGD:1598112
Macaca mulatta SLC9B2 VGNC VGNC:77773
Felis catus SLC9B2 VGNC VGNC:65440
Canis familiaris SLC9B2 VGNC VGNC:54362
Bos taurus SLC9B2 VGNC VGNC:34948
Mus musculus SLC9B2 MGD MGI:2140077
Others SLC9B2 NCBI