ZDHHC21 - zDHHC palmitoyltransferase 21 Gene

Also Known as DNZ1; DHHC21; DHHC-21; HSPC097

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340481

Summary

Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in brain (RPKM 3.1), skin (RPKM 2.5) and 25 other tissues.

ZDHHC21 Products (14)

mRNA Protein Name
NM_001354118.2 NP_001341047.1 palmitoyltransferase ZDHHC21 isoform 1
NM_001354119.2 NP_001341048.1 palmitoyltransferase ZDHHC21 isoform 1
NM_001354120.2 NP_001341049.1 palmitoyltransferase ZDHHC21 isoform 1
NM_001354121.2 NP_001341050.1 palmitoyltransferase ZDHHC21 isoform 1
NM_001354122.2 NP_001341051.1 palmitoyltransferase ZDHHC21 isoform 1
NM_001354123.2 NP_001341052.1 palmitoyltransferase ZDHHC21 isoform 1
NM_001354124.2 NP_001341053.1 palmitoyltransferase ZDHHC21 isoform 1
NM_001354125.2 NP_001341054.1 palmitoyltransferase ZDHHC21 isoform 2
NM_001354126.2 NP_001341055.1 palmitoyltransferase ZDHHC21 isoform 2
NM_001354127.2 NP_001341056.1 palmitoyltransferase ZDHHC21 isoform 3
NM_001354128.2 NP_001341057.1 palmitoyltransferase ZDHHC21 isoform 3
NM_001354129.2 NP_001341058.1 palmitoyltransferase ZDHHC21 isoform 3
NM_001354130.2 NP_001341059.1 palmitoyltransferase ZDHHC21 isoform 3
NM_178566.6 NP_848661.1 palmitoyltransferase ZDHHC21 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables palmitoyltransferase activity IDA
IDA: Inferred from direct assay
23034182 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in peptidyl-L-cysteine S-palmitoylation IMP
IMP: Inferred from mutant phenotype
22031296 GOA
involved in protein palmitoylation IDA
IDA: Inferred from direct assay
23034182 GOA
Cellular Component GO Annotation Evidence Références Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
22031296 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16647879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ZDHHC21 Q8IVQ6 TRIM59 Homo sapiens Q8IWR1
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 TRIM59 Homo sapiens Q8IWR1
Validated Y2H
32296183
Intra
ZDHHC21 Q8IVQ6 TRIM59 Homo sapiens Q8IWR1
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 CHODL Homo sapiens Q9H9P2
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 CHODL Homo sapiens Q9H9P2
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 CHODL Homo sapiens Q9H9P2
Validated Y2H
32296183
Intra
ZDHHC21 Q8IVQ6 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
ZDHHC21 Q8IVQ6 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
ZDHHC21 Q8IVQ6 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
ZDHHC21 Q8IVQ6 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
ZDHHC21 Q8IVQ6 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
ZDHHC21 Q8IVQ6 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
ZDHHC21 Q8IVQ6 MTERF3 Homo sapiens Q96E29
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS16020 ZDHHC20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16011 ZDHHC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16012 ZDHHC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16019 ZDHHC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown