ARL8B - ADP ribosylation factor like GTPase 8B Gene

Also Known as Gie1; ARL10C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55207

About ARL8B

Cytogenetic location: 3p26.1 Genomic coordinates (GRCh38): 3:5,122,292-5,180,911 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 48.8), thyroid (RPKM 43.1) and 25 other tissues.

Summary

Enables guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; lysosomal transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Colocalizes with lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARL8B Products (1)

mRNA	Protein	Name
NM_018184.3	NP_060654.1	ADP-ribosylation factor-like protein 8B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein activity	IDA IDA: Inferred from direct assay	16537643	GOA
enables GDP binding	IDA IDA: Inferred from direct assay	15331635	GOA
enables GDP binding	IMP IMP: Inferred from mutant phenotype	16650381	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	15331635	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	16650381	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	16537643	GOA
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	15331635	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	15331635	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21802320	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antigen processing and presentation following phagocytosis	IMP IMP: Inferred from mutant phenotype	21802320	GOA
involved in autophagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	28325809	GOA
involved in calcium ion regulated lysosome exocytosis	IMP IMP: Inferred from mutant phenotype	29592961	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	14871887	GOA
involved in early endosome to Golgi transport	IDA IDA: Inferred from direct assay	36282215	GOA
involved in endosome to lysosome transport of low-density lipoprotein particle	IMP IMP: Inferred from mutant phenotype	21802320	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	28325809	GOA
involved in lysosome localization	IDA IDA: Inferred from direct assay	16537643	GOA
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	16650381	GOA
involved in natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	24088571	GOA
involved in phagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	21802320	GOA
involved in plasma membrane repair	IMP IMP: Inferred from mutant phenotype	29592961	GOA
involved in protein localization to early endosome	IDA IDA: Inferred from direct assay	36282215	GOA
involved in viral exocytosis	IMP IMP: Inferred from mutant phenotype	33157038	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytolytic granule membrane	IDA IDA: Inferred from direct assay	24088571	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15331635	GOA
is active in early endosome membrane	IDA IDA: Inferred from direct assay	36282215	GOA
colocalizes with lysosomal membrane	IDA IDA: Inferred from direct assay	25898167	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	27808481	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	22172677	GOA
located in lysosome	IDA IDA: Inferred from direct assay	21802320	GOA
located in lysosome	IMP IMP: Inferred from mutant phenotype	16650381	GOA
located in midbody	IDA IDA: Inferred from direct assay	15331635	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	15331635	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL8B Protein Structure

Arf

0
100
186 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-like protein 8B	ADP-ribosylation factor-like 10C

ARL8B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARL8B	Q9NVJ2	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	ARL8B	Q9NVJ2	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	ARL8B	Q9NVJ2	PLEKHM1	Homo sapiens	Q9Y4G2	Y3H	28325809
Intra	ARL8B	Q9NVJ2	PLEKHM1	Homo sapiens	Q9Y4G2	Filter Binding	28325809
Intra	ARL8B	Q9NVJ2	PLEKHM1	Homo sapiens	Q9Y4G2	Pull Down	28325809
Intra	ARL8B	Q9NVJ2	PLEKHM1	Homo sapiens	Q9Y4G2	Confocal	28325809
Intra	ARL8B	Q9NVJ2	PLEKHM1	Homo sapiens	Q9Y4G2	Anti Tag CoIP	28325809
Intra	ARL8B	Q9NVJ2	PLEKHM1	Homo sapiens	Q9Y4G2	TEM	28325809
Intra	ARL8B	Q9NVJ2	SNW1	Homo sapiens	Q13573	Y3H	28325809
Intra	ARL8B	Q9NVJ2	SNW1	Homo sapiens	Q13573	Pull Down	28325809
Intra	ARL8B	Q9NVJ2	SNW1	Homo sapiens	Q13573	Anti Tag CoIP	28325809
Intra	ARL8B	Q9NVJ2	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	ARL8B	Q9NVJ2	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	ARL8B	Q9NVJ2	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	ARL8B	Q9NVJ2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	ARL8B	Q9NVJ2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ARL8B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811291	ARL8B Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spondylometaphyseal Dysplasia, Sedaghatian Type	SMDS Sedaghatian Chondrodysplasia Spondylometaphyseal Dysplasia Sedaghatian Type Congenital Lethal Metaphyseal Chondrodysplasia Metaphyseal Chondrodysplasia, Congenital Lethal Lethal Metaphyseal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00999	ARL8B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22396	Arl8b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28920	Arl8b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARL8B	VGNC	VGNC:84238
Rattus norvegicus	ARL8B	RGD	RGD:1562830
Mus musculus	ARL8B	MGD	MGI:1914416
Canis familiaris	ARL8B	VGNC	VGNC:38122
Felis catus	ARL8B	VGNC	VGNC:59930
Bos taurus	ARL8B	VGNC	VGNC:26154
Others	ARL8B	NCBI