CD300C - CD300c molecule Gene

Also Known as LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10871

About CD300C

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,534,635-74,546,115 (from NCBI)

This gene has 1 transcript (splice variant), 157 orthologues and 13 paralogues. Broad expression in lung (RPKM 2.9), appendix (RPKM 2.6) and 19 other tissues.

Summary

The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

CD300C Products (1)

mRNA Protein Name
NM_006678.5 NP_006669.1 CMRF35-like molecule 6 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20959446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD300C Protein Structure

V-set

V-set: Immunoglobulin V-set domain (27 - 119)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

CMRF35-like molecule 6

  • CD300 antigen-like family member C

CD300C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD300C Q08708 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
Intra
CD300C Q08708 GPR151 Homo sapiens Q8TDV0
Validated Y2H
32296183
Intra
CD300C Q08708 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
Intra
CD300C Q08708 UNC93A Homo sapiens Q86WB7-2
Validated Y2H
32296183
Intra
CD300C Q08708 UNC93A Homo sapiens Q86WB7-2
Y2H Array
32296183
Intra
CD300C Q08708 UNC93A Homo sapiens Q86WB7-2
Y2H Prey Pooling
32296183
Intra
CD300C Q08708 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra
CD300C Q08708 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
CD300C Q08708 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra
CD300C Q08708 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
CD300C Q08708 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
CD300C Q08708 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
CD300C Q08708 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
CD300C Q08708 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
CD300C Q08708 CD300LB Homo sapiens A8K4G0
Anti Tag CoIP
20959446
Intra
CD300C Q08708 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
CD300C Q08708 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD300C Proteins

Cat. No. Product Name Accession Purity
HY-P76222 CD300c Protein, Human (HEK293, His) Q08708/NP_006669.1 (M29-R183) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gastroduodenal Crohn'S Disease

  • Upper Gi Crohn'S Disease
Paget'S Disease Of Bone

  • Osteitis Deformans

  • Paget Disease Of Bone

  • Osseous Paget'S Disease

  • Paget Disease Of Bone, Familial

  • Bone Paget Disease

  • Familial Paget'S Disease Of Bone

  • Paget'S Bone Disease

  • Familial Paget Disease Of Bone

  • Paget Disease, Bone

  • Pdb

  • Pagets Bone Disease
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

  • FTDALS1

  • Frontotemporal Dementia And/Or Motor Neuron Disease

  • Ftdmnd

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

  • Alsftd

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

  • Frontotemporal Dementia With Motor Neuron Disease

  • Ftdals

  • Ftd-Als

  • Ftd-Mnd

  • Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

  • Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

  • Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

  • Frontotemporal Lobar Degeneration

  • Grn-Related Frontotemporal Dementia
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02227 CD300C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18698 Cd300c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25185 Cd300c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992208 Anti-CD300C Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CD300C VGNC VGNC:99134
Rattus norvegicus CD300C RGD RGD:1565161
Others CD300C NCBI