TIMM22 - translocase of inner mitochondrial membrane 22 Gene

Also Known as TEX4; TIM22; COXPD43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29928

About TIMM22

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:997,129-1,003,671 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 208 orthologues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 10.4), placenta (RPKM 10.3) and 25 other tissues.

Summary

Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]

TIMM22 Products (1)

mRNA	Protein	Name
NM_013337.4	NP_037469.2	mitochondrial import inner membrane translocase subunit Tim22

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27718247	GOA
enables protein transporter activity	IMP IMP: Inferred from mutant phenotype	27554484	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein insertion into mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28712724	GOA
involved in protein insertion into mitochondrial inner membrane	IMP IMP: Inferred from mutant phenotype	27554484	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TIM22 mitochondrial import inner membrane insertion complex	IDA IDA: Inferred from direct assay	27718247	GOA
part of TIM22 mitochondrial import inner membrane insertion complex	IPI IPI: Inferred from physical interaction	32901109	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	32901109	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIMM22 Protein Structure

Tim17

0
100
194 a.a.

Protein Preferred Names	Protein Names
mitochondrial import inner membrane translocase subunit Tim22	testis-expressed protein 4

TIMM22 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TIMM22	Q9Y584	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	TIMM22	Q9Y584	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	TIMM22	Q9Y584	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	TIMM22	Q9Y584	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	TIMM22	Q9Y584	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TIMM22	Q9Y584	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TIMM22 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87106	TIMM22 Antibody (YA6799)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 43	COXPD43
Combined Oxidative Phosphorylation Deficiency 18	Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome COXPD18 Combined Oxidative Phosphorylation Deficiency, Type 18
Omodysplasia 2	OMOD2 Omodysplasia, Autosomal Dominant Autosomal Dominant Omodysplasia Omodysplasia Type 2 Omodysplasia, Type 2
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2	NSLH2
Sengers Syndrome	Mitochondrial Dna Depletion Syndrome 10 Cardiomyopathy And Cataract Cataract And Cardiomyopathy MTDPS10 Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10 Senger Syndrome
Omodysplasia 1	OMOD1 Autosomal Recessive Omodysplasia Omodysplasia Autosomal Recessive Omodysplasia Generalized Form Omodysplasia Type 1 Omodysplasia, Generalized Form Omodysplasia, Autosomal Recessive Micromelic Dysplasia, Congenital, With Dislocation Of Radius Micromelic Dysplasia Congenita With Dislocation Of Radius Micromelic Dysplasia-Dislocation Of Radius Syndrome Micromelic Dysplasia Congenital With Dislocation Of Radius Omodysplasia, Type 1
Omodysplasia	Omodysplasia Type 1 Omodysplasia 2
Myopathy	Muscular Diseases Myopathies
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14530	TIMM22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TIMM22	VGNC	VGNC:49575
Mus musculus	TIMM22	MGD	MGI:1929742
Canis familiaris	TIMM22	VGNC	VGNC:49097
Rattus norvegicus	TIMM22	RGD	RGD:68406
Felis catus	TIMM22	VGNC	VGNC:99557
Macaca mulatta	TIMM22	VGNC	VGNC:99299
Others	TIMM22	NCBI