TIMM22 - translocase of inner mitochondrial membrane 22 Gene

Homo sapiens

Also known as TEX4; TIM22; COXPD43

Gene ID: 29928 | Gene type: protein coding

About TIMM22

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:997,129-1,003,671 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 208 orthologues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 10.4), placenta (RPKM 10.3) and 25 other tissues.

Summary

Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]

TIMM22 Products(1)

mRNA	Protein	Name
NM_013337.4	NP_037469.2	mitochondrial import inner membrane translocase subunit Tim22

TIMM22 Protein Structure

Tim17

0
100
194 a.a.

Protein Preferred Names

Protein Names

mitochondrial import inner membrane translocase subunit Tim22

testis-expressed protein 4

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 43

COXPD43

Combined Oxidative Phosphorylation Deficiency 18

Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome	COXPD18
Combined Oxidative Phosphorylation Deficiency, Type 18

Omodysplasia 2

OMOD2	Omodysplasia, Autosomal Dominant
Autosomal Dominant Omodysplasia	Omodysplasia Type 2
Omodysplasia, Type 2

Noonan Syndrome-Like Disorder With Loose Anagen Hair 2

NSLH2

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Omodysplasia 1

OMOD1	Autosomal Recessive Omodysplasia
Omodysplasia Autosomal Recessive	Omodysplasia Generalized Form
Omodysplasia Type 1	Omodysplasia, Generalized Form
Omodysplasia, Autosomal Recessive	Micromelic Dysplasia, Congenital, With Dislocation Of Radius
Micromelic Dysplasia Congenita With Dislocation Of Radius	Micromelic Dysplasia-Dislocation Of Radius Syndrome
Micromelic Dysplasia Congenital With Dislocation Of Radius	Omodysplasia, Type 1

Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Myopathy

Muscular Diseases

Myopathies

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14530	TIMM22 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TIMM22	VGNC	VGNC:49575
Mus musculus	TIMM22	MGD	MGI:1929742
Canis familiaris	TIMM22	VGNC	VGNC:49097
Rattus norvegicus	TIMM22	RGD	RGD:68406
Felis catus	TIMM22	VGNC	VGNC:99557
Macaca mulatta	TIMM22	VGNC	VGNC:99299

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