SFXN3 - sideroflexin 3 Gene

Also Known as SFX3; SLC56A3; BA108L7.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81855

About SFXN3

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:101,031,234-101,041,241 (from NCBI)

This gene has 8 transcripts (splice variants), 222 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 25.7), duodenum (RPKM 19.3) and 23 other tissues.

Summary

Enables serine transmembrane transporter activity. Involved in serine import into mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SFXN3 Products (10)

mRNA Protein Name
NM_001388027.1 NP_001374956.1 sideroflexin-3 isoform 2
NM_001388028.1 NP_001374957.1 sideroflexin-3 isoform 2
NM_001388029.1 NP_001374958.1 sideroflexin-3 isoform 6
NM_001388030.1 NP_001374959.1 sideroflexin-3 isoform 6
NM_001388031.1 NP_001374960.1 sideroflexin-3 isoform 6
NM_001388032.1 NP_001374961.1 sideroflexin-3 isoform 3
NM_001388033.1 NP_001374962.1 sideroflexin-3 isoform 4
NM_001388034.1 NP_001374963.1 sideroflexin-3 isoform 5
NM_001388035.1 NP_001374964.1 sideroflexin-3 isoform 5
NM_030971.6 NP_112233.3 sideroflexin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-serine transmembrane transporter activity IDA
IDA: Inferred from direct assay
30442778 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial transmembrane transport IDA
IDA: Inferred from direct assay
30442778 GOA
acts upstream of one-carbon metabolic process IDA
IDA: Inferred from direct assay
30442778 GOA
involved in serine import into mitochondrion IDA
IDA: Inferred from direct assay
30442778 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
30442778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFXN3 Protein Structure

Mtc

Mtc: Tricarboxylate carrier (19 - 325)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

sideroflexin-3

SFXN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SFXN3 Q9BWM7 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
SFXN3 Q9BWM7 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
SFXN3 Q9BWM7 LAMP2 Homo sapiens P13473-2
Anti Tag CoIP
28514442
Intra
SFXN3 Q9BWM7 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
SFXN3 Q9BWM7 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
SFXN3 Q9BWM7 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
SFXN3 Q9BWM7 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
SFXN3 Q9BWM7 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
SFXN3 Q9BWM7 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
SFXN3 Q9BWM7 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
SFXN3 Q9BWM7 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 LEPROTL1 Homo sapiens O95214
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 RUSF1 Homo sapiens Q96GQ5
Y2H Array
32296183
Intra
SFXN3 Q9BWM7 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 RUSF1 Homo sapiens Q96GQ5
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
SFXN3 Q9BWM7 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SFXN3 Q9BWM7 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sengers Syndrome

  • Mitochondrial Dna Depletion Syndrome 10

  • Cardiomyopathy And Cataract

  • Cataract And Cardiomyopathy

  • MTDPS10

  • Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

  • Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

  • Senger Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12787 SFXN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21045 Sfxn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27563 Sfxn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SFXN3 MGD MGI:2137679
Canis familiaris SFXN3 VGNC VGNC:46089
Felis catus SFXN3 VGNC VGNC:65071
Rattus norvegicus SFXN3 RGD RGD:620716
Bos taurus SFXN3 VGNC VGNC:34532
Macaca mulatta SFXN3 VGNC VGNC:77245
Others SFXN3 NCBI