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TMEM65 - transmembrane protein 65 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 157378

About TMEM65

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,306,189-124,372,701 (from NCBI)

This gene has 7 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in duodenum (RPKM 11.1), brain (RPKM 8.4) and 25 other tissues.

Summary

Predicted to be involved in cardiac ventricle development and regulation of cardiac conduction. Located in intercalated disc; mitochondrial inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM65 Products (1)

mRNA	Protein	Name
NM_194291.3	NP_919267.2	transmembrane protein 65

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in intercalated disc	IDA IDA: Inferred from direct assay	26403541	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	24765583	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26403541	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM65 Protein Structure

TMEM65

0
100
200
240 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 65

TMEM65 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM65	Q6PI78	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TMEM65	Q6PI78	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	TMEM65	Q6PI78	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	TMEM65	Q6PI78	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	PTGES	Homo sapiens	O14684	Y2H Array	32296183
Intra	TMEM65	Q6PI78	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TMEM65	Q6PI78	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	TMEM65	Q6PI78	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TMEM65	Q6PI78	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	TMEM65	Q6PI78	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	TMEM65	Q6PI78	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	TMEM65	Q6PI78	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	IGSF9	Homo sapiens	Q9P2J2-2	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	IGSF9	Homo sapiens	Q9P2J2-2	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	IGSF9	Homo sapiens	Q9P2J2-2	Y2H Array	32296183
Intra	TMEM65	Q6PI78	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	TMEM65	Q6PI78	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
Intra	TMEM65	Q6PI78	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	TMEM65	Q6PI78	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	TMEM65	Q6PI78	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TMEM65	Q6PI78	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM65	Q6PI78	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	TMEM65	Q6PI78	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
Intra	TMEM65	Q6PI78	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Array	32296183
Intra	TMEM65	Q6PI78	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM65	Q6PI78	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	TMEM65	Q6PI78	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
Intra	TMEM65	Q6PI78	JPH1	Homo sapiens	Q9HDC5	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	JPH1	Homo sapiens	Q9HDC5	Y2H Array	32296183
Intra	TMEM65	Q6PI78	JPH1	Homo sapiens	Q9HDC5	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	TMEM65	Q6PI78	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TMEM65	Q6PI78	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TMEM65	Q6PI78	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TMEM65	Q6PI78	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TMEM65	Q6PI78	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	TMEM65	Q6PI78	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	TMEM65	Q6PI78	MSMO1	Homo sapiens	Q15800	Y2H Prey Pooling	32296183
Intra	TMEM65	Q6PI78	MSMO1	Homo sapiens	Q15800	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mitochondrial Complex Iv Deficiency, Nuclear Type 5	Leigh Syndrome, French Canadian Type Mitochondrial Complex V Deficiency Nuclear Type 4 Cytochrome C Oxidase Deficiency, French Canadian Type Lsfc Cox Deficiency, French Canadian Type MC5DN4 MC4DN5 Cox Deficiency, Saguenay-Lac-Saint-Jean Type Leigh Syndrome, Saguenay-Lac-Saint-Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 French Canadian Leigh Disease Leigh Syndrome, French-Canadian Type Leigh Syndrome , French Canadian Type Mitochondrial Complex V Deficiency, Atp5a1 Type French Canadian Type Cox Deficiency French Canadian Type Cytochrome C Oxidase Deficiency French Canadian Type Leigh Syndrome Saguenay Lac Saint Jean Type Cox Deficiency Saguenay Lac Saint Jean Type Leigh Syndrome Cox Deficiency, Saguenay Lac Saint Jean Type Leigh Syndrome, Saguenay Lac Saint Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 Mitochondrial Complex V Deficiency Atp5a1 Type Mitochondrial Complex V Deficiency Type 4 Mitochondrial Complex V Deficiency, Nuclear, Type 4
Progressive Familial Heart Block	Hereditary Bundle Branch Defect Hereditary Bundle Branch System Defect Familial Lenegre Disease Familial Lev Disease Familial Lev-Lenegre Disease Familial Pccd Familial Progressive Heart Block Pfhb Bundle Branch Block Hbbd Lenegre Lev Disease Lev Syndrome Lev'S Disease Lev-Lenègre Disease Pccd Progressive Cardiac Conduction Defect Bundle-Branch Block
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14736	TMEM65 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMEM65	VGNC	VGNC:47598
Bos taurus	TMEM65	VGNC	VGNC:36106
Macaca mulatta	TMEM65	VGNC	VGNC:104502
Rattus norvegicus	TMEM65	RGD	RGD:1563224
Mus musculus	TMEM65	MGD	MGI:1922118
Others	TMEM65	NCBI