ALOX5AP - arachidonate 5-lipoxygenase activating protein Gene

Also Known as FLAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 241

About ALOX5AP

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,713,485-30,764,426 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 94.5), lung (RPKM 39.9) and 14 other tissues.

Summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

ALOX5AP Products (3)

mRNA Protein Name
NM_001204406.2 NP_001191335.1 arachidonate 5-lipoxygenase-activating protein isoform 2
NM_001629.4 NP_001620.2 arachidonate 5-lipoxygenase-activating protein isoform 1
XM_017020522.3 XP_016876011.1 arachidonate 5-lipoxygenase-activating protein isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate binding IDA
IDA: Inferred from direct assay
8440384 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19233132 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
2300173 GOA
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
2300173 GOA
involved in protein homotrimerization IPI
IPI: Inferred from physical interaction
17600184 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19233132 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
19233132 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
8245774 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALOX5AP Protein Structure

MAPEG

MAPEG: MAPEG family (11 - 126)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

arachidonate 5-lipoxygenase-activating protein

  • MK-886-binding protein

ALOX5AP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALOX5AP P20292 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
ALOX5AP P20292 OPRM1 Homo sapiens P35372-10
Validated Y2H
32296183
Intra
ALOX5AP P20292 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
ALOX5AP P20292 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ALOX5AP P20292 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
ALOX5AP P20292 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ALOX5AP P20292 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
ALOX5AP P20292 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
ALOX5AP P20292 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
ALOX5AP P20292 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
ALOX5AP P20292 q96fb2_human Homo sapiens Q96FB2
Validated Y2H
32296183
Intra
ALOX5AP P20292 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ALOX5AP Antibodies

Cat. No. Product Name Application Reactivity
HY-P811356 ALOX5AP Antibody WB, IHC-P Human
HY-P82958 FLAP Antibody (YA2703) WB Human

Related Diseases

Diseases Alias
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Aspirin-Induced Respiratory Disease

  • Aspirin-Sensitive Asthma
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases

  • Cardiovascular Disease
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Disease, Susceptibility To

  • Coronary Artery Anomaly

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Stroke, Ischemic

  • Cerebral Infarction

  • Stroke

  • Ischemic Stroke

  • Cerebrovascular Accident

  • Cerebral Infarction, Susceptibility To

  • Stroke, Ischemic, Susceptibility To

  • Cerebral Infarct

  • Ischemic Stroke, Susceptibility To

  • Stroke, Susceptibility To

  • Cva - Cerebral Infarction

  • ISCHSTR

  • Ischemic Cerebrovascular Accident
Persistent Mild Asthma
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Macular Holes

  • Macular Hole
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00625 Alox5ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00623 ALOX5AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00624 Alox5ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ALOX5AP VGNC VGNC:25845
Macaca mulatta ALOX5AP VGNC VGNC:69799
Rattus norvegicus ALOX5AP RGD RGD:2097
Mus musculus ALOX5AP MGD MGI:107505
Canis familiaris ALOX5AP VGNC VGNC:59072
Felis catus ALOX5AP VGNC VGNC:102156
Others ALOX5AP NCBI