ALOX5AP - arachidonate 5-lipoxygenase activating protein Gene

Homo sapiens

Also known as FLAP

Gene ID: 241 | Gene type: protein coding

About ALOX5AP

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,713,485-30,764,426 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 94.5), lung (RPKM 39.9) and 14 other tissues.

Summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

ALOX5AP Products(3)

mRNA	Protein	Name
NM_001204406.2	NP_001191335.1	arachidonate 5-lipoxygenase-activating protein isoform 2
NM_001629.4	NP_001620.2	arachidonate 5-lipoxygenase-activating protein isoform 1
XM_017020522.3	XP_016876011.1	arachidonate 5-lipoxygenase-activating protein isoform X1

ALOX5AP Protein Structure

MAPEG

0
100
161 a.a.

Protein Preferred Names

Protein Names

arachidonate 5-lipoxygenase-activating protein

MK-886-binding protein

Recombinant ALOX5AP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74152	FLAP Protein-VLP, Human (HEK293, His)	P20292 (M1-P161)	/

Related Diseases

Diseases

Alias

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Disease Of Subdivision Of Hemolymphoid System
Disorder Of Cardiovascular System	Cardiovascular Diseases
Cardiovascular Disease

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Disease, Susceptibility To
Coronary Artery Anomaly	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Persistent Mild Asthma

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Macular Holes

Macular Hole

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00623	ALOX5AP Human Pre-designed siRNA Set A	/	Unkown
HY-RS00624	Alox5ap Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00625	Alox5ap Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ALOX5AP	VGNC	VGNC:25845
Macaca mulatta	ALOX5AP	VGNC	VGNC:69799
Rattus norvegicus	ALOX5AP	RGD	RGD:2097
Mus musculus	ALOX5AP	MGD	MGI:107505
Canis familiaris	ALOX5AP	VGNC	VGNC:59072
Felis catus	ALOX5AP	VGNC	VGNC:102156
Others	ALOX5AP	NCBI

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