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SLC13A3 - solute carrier family 13 member 3 Gene

Also Known as NaC3; NADC3; SDCT2; ARLIAK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64849

About SLC13A3

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:46,557,828-46,684,485 (from NCBI)

This gene has 11 transcripts (splice variants), 216 orthologues, 5 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 195.8) and placenta (RPKM 14.9).

Summary

Mammalian sodium-dicarboxylate cotransporters transport succinate and Other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]

SLC13A3 Products (5)

mRNA	Protein	Name
NM_001011554.3	NP_001011554.1	Na(+)/dicarboxylate cotransporter 3 isoform b
NM_001193339.2	NP_001180268.1	Na(+)/dicarboxylate cotransporter 3 isoform c precursor
NM_001193340.2	NP_001180269.1	Na(+)/dicarboxylate cotransporter 3 isoform d
NM_001193342.2	NP_001180271.1	Na(+)/dicarboxylate cotransporter 3 isoform e
NM_022829.6	NP_073740.2	Na(+)/dicarboxylate cotransporter 3 isoform a precursor

SLC13A3 Protein Structure

Na_sulph_symp

0
100
200
300
400
500
602 a.a.

Protein Preferred Names	Protein Names
Na(+)/dicarboxylate cotransporter 3	Na(+)-coupled carboxylate transporter 3

SLC13A3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC13A3	Q8WWT9	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	RMDN3	Homo sapiens	Q96TC7	Validated Y2H	32296183
Intra	SLC13A3	Q8WWT9	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SLC13A3	Q8WWT9	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SLC13A3	Q8WWT9	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SLC13A3	Q8WWT9	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SLC13A3	Q8WWT9	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC13A3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810033	NaDC-3 Antibody (YA9377)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Leukoencephalopathy, Acute Reversible, With Increased Urinary Alpha-Ketoglutarate	ARLIAK Acute Reversible Leukoencephalopathy With Increased Urinary Alpha-Ketoglutarate Acute Reversible Leukoencephalopathy Due To Slc13a3 Deficiency Acute Reversible Leukoencephalopathy Due To Sodium-Dependent Dicarboxylate Transporter Deficiency
Axenfeld-Rieger Syndrome, Type 1	Axenfeld-Rieger Syndrome Type 1 RIEG1 Rieg Rgs Rieger Syndrome Type 1 Rieger Syndrome, Type 1 Axenfeld-Rieger Syndrome 1 Iridogoniodysgenesis With Somatic Anomalies
Canavan Disease	Aspartoacylase Deficiency Aminoacylase 2 Deficiency Spongy Degeneration Of Central Nervous System Aspa Deficiency Acy2 Deficiency Canavan-Van Bogaert-Bertrand Disease Mild Canavan Disease Asp Deficiency Spongy Degeneration Of The Central Nervous System Severe Canavan Disease Von Bogaert-Bertrand Disease Canavan'S Disease Spongy Degeneration Of The Brain Juvenile Canavan Disease Infantile Canavan Disease Neonatal Canavan Disease CAND Disease, Canavan Canavan Disease, Juvenile Canavan Disease, Infantile Canavan Disease, Neonatal
Developmental And Epileptic Encephalopathy 25	Developmental And Epileptic Encephalopathy, 25 Dee25 Developmental And Epileptic Encephalopathy 25, With Amelogenesis Imperfecta Early Infantile Epileptic Encephalopathy 25 Encephalopathy, Epileptic, Early Infantile, Type 25
N-Acetylglutamate Synthase Deficiency	Nags Deficiency N-Acetylglutamate Synthetase Deficiency Hyperammonemia, Type Iii Hyperammonemia Due To N-Acetylglutamate Synthetase Deficiency NAGSD Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency N-Acetyl Glutamate Synthetase Deficiency Nag Synthetase Deficiency Deficiency, N-Acetylglutamate Synthase
Developmental And Epileptic Encephalopathy 39	Hypomyelination, Global Cerebral Agc1 Deficiency Epileptic Encephalopathy, Early Infantile, 39 DEE39 Eiee39 Aspartate-Glutamate Carrier 1 Deficiency Epileptic Encephalopathy With Global Cerebral Demyelination Developmental And Epileptic Encephalopathy, 39 Early Infantile Epileptic Encephalopathy 39 Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency Global Cerebral Hypomyelination Hereditary Central Nervous System Demyelinating Diseases
L-2-Hydroxyglutaric Aciduria	L-2-Hydroxyglutaric Acidemia L2HGA L-2-Hga Aciduria, L-2-Hydroxyglutaric Combined D-2- And L-2-Hydroxyglutaric Aciduria
Glutaric Acidemia I	Glutaryl-Coa Dehydrogenase Deficiency GA1 Glutaric Acidemia Type 1 Glutaric Aciduria 1 Glutaric Aciduria Type 1 Glutaric Acidemia Type I Glutaric Aciduria, Type 1 Glutaric Aciduria I Ga I Glutaricaciduria, Type I Glutaryl-Coenzyme A Dehydrogenase Deficiency Glutaric Academia Type 1 Glutaric Aciduria Type I Ga-1 Gcdh Deficiency Ga 1 Glutaric Acidemia 1 Gcdhd Glutaric Aciduria, Type I Glutaricaciduria I Ga-I Glutaricaciduria, Type 1
Axenfeld-Rieger Syndrome	Axenfeld Syndrome Rieger Syndrome Rieger Anomaly Axenfeld Anomaly Anomaly, Rieger'S Hagedoom Syndrome Rgs - Rieger Syndrome Rieger'S Anomaly Goniodysgenesis Hypodontia Iridogoniodysgenesis With Somatic Anomalies Ars Axenfeld And Rieger Anomaly Axra Axrs Rieger Eye Malformation Sequence
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13007	SLC13A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC13A3	VGNC	VGNC:46229
Macaca mulatta	SLC13A3	VGNC	VGNC:77476
Bos taurus	SLC13A3	VGNC	VGNC:34675
Felis catus	SLC13A3	VGNC	VGNC:65198
Rattus norvegicus	SLC13A3	RGD	RGD:628786
Mus musculus	SLC13A3	MGD	MGI:2149635