STRIP1 - striatin interacting protein 1 Gene

Also Known as FAM40A; FAR11A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85369

About STRIP1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,031,577-110,054,641 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.7), bone marrow (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a member of the striatin-interacting Phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

STRIP1 Products (2)

mRNA Protein Name
NM_001270768.2 NP_001257697.1 striatin-interacting protein 1 isoform 2
NM_033088.4 NP_149079.2 striatin-interacting protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
30622739 GOA
Biological Process GO Annotation Evidence References Source
involved in cortical actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
30622739 GOA
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
21834987 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15302935 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRIP1 Protein Structure

N1221

N1221: N1221-like protein (66 - 347)

DUF3402

DUF3402: Domain of unknown function (DUF3402) (420 - 808)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 837 a.a.
Protein Preferred Names Protein Names

striatin-interacting protein 1

  • FAR11 factor arrest 11 homolog A

STRIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STRIP1 Q5VSL9 PPP2CB Homo sapiens P62714
Anti Tag CoIP
33961781
Intra
STRIP1 Q5VSL9 PPP2CB Homo sapiens P62714
Anti Tag CoIP
25531779
Intra
STRIP1 Q5VSL9 PPP2CB Homo sapiens P62714
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
33961781
Intra
STRIP1 Q5VSL9 STK26 Homo sapiens Q9P289
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 PPP2CA Homo sapiens P67775
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 PPP2CA Homo sapiens P67775
Anti Tag CoIP
33961781
Intra
STRIP1 Q5VSL9 PPP2CA Homo sapiens P67775
Anti Tag CoIP
25531779
Intra
STRIP1 Q5VSL9 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
25531779
Intra
STRIP1 Q5VSL9 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
18782753
Intra
STRIP1 Q5VSL9 TRAF3IP3 Homo sapiens Q9Y228
Anti Tag CoIP
18782753
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations 3

  • Cerebral Cavernous Malformation 3

  • CCM3

  • Cerebral Cavernous Malformations-3

  • Cavernous Angiomatous Malformations

  • Cavernous Hemangioma Of The Brain

  • Cerebral Capillary Malformations

  • Cerebral Cavernoma

  • Familial Cavernous Angioma

  • Cerebral Cavernous Malformations, Type 3
Root Caries

  • Cementum Caries

  • Dental Caries Of Root Surface
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N10881 Dihydrocurcumenone / Unkown
HY-RS13964 STRIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STRIP1 MGD MGI:2443884
Canis familiaris STRIP1 VGNC VGNC:46943
Rattus norvegicus STRIP1 RGD RGD:1564249
Macaca mulatta STRIP1 VGNC VGNC:78217
Bos taurus STRIP1 VGNC VGNC:35422
Felis catus STRIP1 VGNC VGNC:65801
Others STRIP1 NCBI