STK24 - serine/threonine kinase 24 Gene

Also Known as MST3; STK3; MST3B; STE20; HEL-S-95

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8428

About STK24

Cytogenetic location: 13q32.2 Genomic coordinates (GRCh38): 13:98,445,185-98,577,107 (from NCBI)

This gene has 8 transcripts (splice variants), 266 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 41.4), skin (RPKM 24.6) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

STK24 Products (3)

mRNA	Protein	Name
NM_001032296.4	NP_001027467.2	serine/threonine-protein kinase 24 isoform b precursor
NM_001286649.2	NP_001273578.1	serine/threonine-protein kinase 24 isoform c precursor
NM_003576.5	NP_003567.2	serine/threonine-protein kinase 24 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16314523	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	22291017	GOA
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	12107159	GOA
involved in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19604147	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17046825	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	17046825	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	19604147	GOA
involved in regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	19855390	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12107159	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12107159	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK24 Protein Structure

Pkinase

0
100
200
300
400
443 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase 24	STE20-like kinase 3

STK24 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Anti Bait CoIP	17353931
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	TAP	23455922
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Pull Down	32707033
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Anti Tag CoIP	35271311
Intra	STK24	Q9Y6E0	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
Intra	STK24	Q9Y6E0	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	35271311
Intra	STK24	Q9Y6E0	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	18782753
Intra	STK24	Q9Y6E0	STRIP1	Homo sapiens	Q5VSL9	Pull Down	32707033
Intra	STK24	Q9Y6E0	CTTNBP2NL	Homo sapiens	Q9P2B4	Pull Down	32707033
Intra	STK24	Q9Y6E0	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	18782753
Intra	STK24	Q9Y6E0	CTTNBP2NL	Homo sapiens	Q9P2B4	TAP	23455922
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Anti Bait CoIP	17353931
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H Array	31515488
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H	17657516
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	TAP	23455922
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Pull Down	32707033
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	35271311
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H	21516116
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Y2H Pooling	16189514
Intra	STK24	Q9Y6E0	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	18782753

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Inflammatory Bowel Disease 14	IBD14 Inflammatory Bowel Disease 14, Susceptibility To Bowel Disease, Inflammatory, Type 14
Cerebral Cavernous Malformations 3	Cerebral Cavernous Malformation 3 CCM3 Cerebral Cavernous Malformations-3 Cavernous Angiomatous Malformations Cavernous Hemangioma Of The Brain Cerebral Capillary Malformations Cerebral Cavernoma Familial Cavernous Angioma Cerebral Cavernous Malformations, Type 3
Arthrogryposis, Distal, Type 3	Gordon Syndrome DA3 Distal Arthrogryposis Type 3 Arthrogryposis Multiplex Congenita, Distal, Type Iia Camptodactyly, Cleft Palate, And Clubfoot Camptodactyly-Cleft Palate-Clubfoot Syndrome Distal Arthrogryposis Multiplex Congenita Type Iia Arthrogryposis Distal Type 3 Distal Arthrogryposis Type Iia Arthrogryposis, Distal, 3 Pseudohypoaldosteronism, Type Ii
Gitelman Syndrome	Familial Hypokalemia-Hypomagnesemia Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria Potassium And Magnesium Depletion GTLMNS Gitelman'S Syndrome Gs Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria Bartter Syndrome Gitelman Variant Bartter Syndrome Hypocalciuric Variant Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria
Pseudohypoaldosteronism
Agenesis Of The Corpus Callosum With Peripheral Neuropathy	Andermann Syndrome Charlevoix Disease ACCPN Polyneuropathy, Sensorimotor, With Or Without Agenesis Of The Corpus Callosum Corpus Callosum, Agenesis Of, With Neuronopathy Corpus Callosum Agenesis-Neuronopathy Syndrome Agenesis Of Corpus Callosum With Neuronopathy Agenesis Of Corpus Callosum With Peripheral Neuropathy Agenesis Of Corpus Callosum With Polyneuropathy Corpus Callosum Agenesis Neuronopathy Hmsn/Acc Hereditary Motor And Sensory Neuropathy With Agenesis Of The Corpus Callosum Agenesis Of The Corpus Callosum, With Peripheral Neuropathy Andermann'S Syndrome Agenesis, Corpus Callosum, With Peripheral Neuropathy
Cerebrocostomandibular Syndrome	Cerebro-Costo-Mandibular Syndrome CCMS Rib Gap Defects With Micrognathia Ccm Syndrome
Renal Tubular Transport Disease	Renal Tubular Transport, Inborn Errors Inborn Renal Tubular Transport Disorder
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13927	STK24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21057	Stk24 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27574	Stk24 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STK24	MGD	MGI:2385007
Macaca mulatta	STK24	VGNC	VGNC:81583
Felis catus	STK24	VGNC	VGNC:97647
Bos taurus	STK24	VGNC	VGNC:35390
Rattus norvegicus	STK24	RGD	RGD:1561742
Canis familiaris	STK24	VGNC	VGNC:49657
Others	STK24	NCBI