KISS1R - KISS1 receptor Gene

Homo sapiens

Also known as HH8; CPPB1; GPR54; AXOR12; KISS-1R; HOT7T175

Gene ID: 84634 | Gene type: protein coding

About KISS1R

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:917,333-921,005 (from NCBI)

This gene has 3 transcripts (splice variants), 135 orthologues, 17 paralogues and is associated with 4 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008]

KISS1R Products(2)

mRNA	Protein	Name
XM_047439545.1	XP_047295501.1	kiSS-1 receptor isoform X1
NM_032551.5	NP_115940.2	kiSS-1 receptor

KISS1R Protein Structure

7tm_1

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

kiSS-1 receptor

G protein-coupled receptor 54	G-protein coupled receptor OT7T175
hypogonadotropin-1	kisspeptins receptor
metastin receptor

Related Diseases

Diseases

Alias

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Hearing Loss Disorder
Hearing Loss, Sensorineural	Central Hearing Loss
High Frequency Deafness	High Frequency Hearing Loss
High-Frequency Hearing Loss	Perceptive Deafness
Perceptive Hearing Loss	Perceptive Hearing Loss Or Deafness
Sensorineural Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Precocious Puberty

Familial Precocious Puberty	Idiopathic Sexual Precocity
Sexual Precocity	Puberty Precocious
Cryptogenic Sexual Precocity

Hypogonadotropic Hypogonadism 8 With Or Without Anosmia

HH8	Hypogonadotropic Hypogonadism 8 Without Anosmia
Hypogonadism, Hypogonadotropic, Type 8 With/Without Anosmia

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Septooptic Dysplasia

Septo-Optic Dysplasia	De Morsier Syndrome
Growth Hormone Deficiency With Pituitary Anomalies	SOD
Pituitary Hormone Deficiency, Combined, 5	Septo-Optic Dysplasia Spectrum
Septo-Optic Dysplasia With Growth Hormone Deficiency	Pituitary Hormone Deficiency, Combined 5
Hypopituitarism And Septooptic 'Dysplasia'	GHDPA
CPHD5	Dysplasia, Septo-Optic
Kallmann Syndrome

Precocious Puberty, Male-Limited

Testotoxicosis	Familial Male-Limited Precocious Puberty
Leydig Cell Adenoma, Somatic, With Precocious Puberty	FMPP
Familial Testotoxicosis	Sexual Precocity, Familial, Gonadotropin-Independent
Familial Gonadotropin-Independent Male-Limited Sexual Precocity	Male-Limited Precocious Puberty
Pubertas Praecox	Gonadotropin-Independent Familial Sexual Precocity
Testotoxicosis, Familial	Precocious Puberty, Male
Precocious Puberty, Male Limited	Familial Gonadotrophin-Independent Sexual Precocity
Gipp	Gonadotrophin-Independent Precocious Puberty
Precocious Pseudopuberty	Familial Male Precocious Puberty
Precocious Puberty In Males	Puberty, Precocious
Precocious Puberty

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Hypogonadism

Normosmic Congenital Hypogonadotropic Hypogonadism

Normosmic Idiopathic Hypogonadotropic Hypogonadism

Nihh

Precocious Puberty, Gonadotropin-Dependent

Glucocorticoid Deficiency 1

Acth Resistance	Glucocorticoid Deficiency, Due To Acth Unresponsiveness
GCCD1	Familial Glucocorticoid Deficiency 1
Fgd1	Adrenal Unresponsiveness To Acth
Hereditary Unresponsiveness To Adrenocorticotropic Hormone	Isolated Glucocorticoid Deficiency

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Precocious Puberty, Central, 1

CPPB1	Central Precocious Puberty 1
Precocious Puberty, Central 1	Puberty, Precocious, Central, Type 1

Pituitary Stalk Interruption Syndrome

Ectopic Neurohypophysis

Psis

Central Precocious Puberty

Cpp	Gonadotropin-Dependant Precocious Puberty
Gonadotropin-Dependent Precocious Puberty	Precocious Puberty, Central

Leydig Cell Hypoplasia

46,Xy Disorder Of Sex Development Due To Lh Resistance Or Lhb Deficiency	46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
46,Xy Dsd Due To Lh Resistance Or Lhb Deficiency	46,Xy Dsd Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
46,Xy Disorder Of Sex Development Due To Lh Defects	Lh Resistance Due To Lh Receptor Deactivation
Leydig Cell Agenesis	Male Hypergonadotropic Hypogonadism Due To Lhcgr Defect
Male Pseudohermaphroditism Due To Lh Resistance Or Lhb Deficiency	Male Pseudohermaphroditism Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
Lch	Hypoplasia, Leydig Cell

Disorder Of Sexual Development

Disorder Of Sex Development	Sex Development Disorder
Sex Differentiation Disease	Dsd
Disorders Of Sex Development	Sex Differentiation Disorders

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Idiopathic Central Precocious Puberty

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0076A	TAK-448 acetate		98.87%	Phase 2
HY-P0076	TAK-448		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Purity	Rare Diseases
HY-P2161B	TAK-683 acetate	98.97%	Unkown
HY-P2161	TAK-683	/	Unkown
HY-P2161A	TAK-683 TFA	/	Unkown
HY-RS07316	KISS1R Human Pre-designed siRNA Set A	/	Unkown
HY-RS07317	Kiss1r Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS07318	Kiss1r Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KISS1R	MGD	MGI:2148793
Macaca mulatta	KISS1R	VGNC	VGNC:82170
Bos taurus	KISS1R	VGNC	VGNC:30617
Canis familiaris	KISS1R	VGNC	VGNC:42421
Rattus norvegicus	KISS1R	RGD	RGD:70930
Felis catus	KISS1R	VGNC	VGNC:102622

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