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KISS1-305 

Cat. No.: HY-P2191
Handling Instructions

KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation.

For research use only. We do not sell to patients.

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KISS1-305 Chemical Structure

KISS1-305 Chemical Structure

CAS No. : 872717-97-0

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Description

KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation[1].

In Vivo

KISS1-305 (4 nmol/h; s.c.) shows suppression of pituitary-gonadal functions[1].
KISS1-305 causes substantial elevations of plasma LH and testosterone, followed by abrupt reductions of both hormone levels. KISS1-305 also reduced genital organ weight more profoundly than leuprolide. In mechanistic studies, chronic KISS1-305 administration only transiently induced c-Fos expression in GnRH neurons, suggesting that GnRH-neural response was attenuated over time[1].

Animal Model: Adult male Sprague Dawley Crl:CD(SD) rats (8-10 wk of age)[1]
Dosage: 4 nmol/h
Administration: s.c.
Result: Both plasma T and LH levels were markedly increased on d 1 after the initiation of dosing and dramatically decreased thereafter to the lower limit of detection (LH: 0.08 ng/ml; T: 0.04 ng/ml) by d 6. 
Molecular Weight

1165.30

Formula

C₅₆H₇₆N₁₆O₁₂

CAS No.

872717-97-0

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KISS1-305Othersproteasedegradationprototypepeptideprobeplasmatestosteronehormonec-FosInhibitorinhibitorinhibit

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