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  2. TAK-448 acetate

TAK-448 acetate (Synonyms: MVT-602 acetate)

Cat. No.: HY-P0076A Purity: 99.37%
Handling Instructions

TAK-448 acetate (MVT-602 acetate) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TAK-448 acetate Chemical Structure

TAK-448 acetate Chemical Structure

CAS No. : 1470374-22-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 1273 In-stock
Estimated Time of Arrival: December 31
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TAK-448 acetate (MVT-602 acetate) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].

IC50 & Target

IC50: 460 pM (KISS1R)[1]
EC50: 632 pM (KISS1R)[1]

In Vivo

TAK-448 acetate (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model[2].

Animal Model: Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)
Dosage: 0.01, 0.03, 0.3, 3 mg/kg
Administration: Given i.h.; dosings on day 0 and 28
Result: Had greater anti-tumor effects in VCaP xenograft model.
Clinical Trial
Molecular Weight

1285.41

Formula

C₆₀H₈₄N₁₆O₁₆

CAS No.

1470374-22-1

Sequence

Ac-{d-Tyr}-Hyp-Asn-Thr-Phe-{Aza-Gly}-Leu-{Arg(Me)}-Trp-NH2

Sequence Shortening

Ac-{d-Tyr}-{Hyp}-NTF-{Aza-Gly}-L-{Arg(Me)}-W-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (77.80 mM)

H2O : 50 mg/mL (38.90 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7780 mL 3.8898 mL 7.7796 mL
5 mM 0.1556 mL 0.7780 mL 1.5559 mL
10 mM 0.0778 mL 0.3890 mL 0.7780 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TAK-448MVT-602TAK448TAK 448MVT602MVT 602OthersInhibitorinhibitorinhibit

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Product Name:
TAK-448 acetate
Cat. No.:
HY-P0076A
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