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  2. TAK-448

TAK-448 (Synonyms: MVT-602)

Cat. No.: HY-P0076
Handling Instructions

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TAK-448 Chemical Structure

TAK-448 Chemical Structure

CAS No. : 1234319-68-6

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1 mg USD 150 Get quote
5 mg USD 450 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].

IC50 & Target

IC50: 460 pM (KISS1R)[1]
EC50: 632 pM (KISS1R)[1]

In Vivo

TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model[2].

Animal Model: Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)
Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.3 mg/kg, 3 mg/kg
Administration: Given i.h.; dosings on day 0 and 28
Result: Had greater anti-tumor effects in VCaP xenograft model.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
Molecular Weight

1225.36

Formula

C₅₈H₈₀N₁₆O₁₄

CAS No.

1234319-68-6

Sequence

Ac-D-Tyr-D-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2

Sequence Shortening

Ac-Y-{Hyp}-NTFGLRW-NH2

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
TAK-448
Cat. No.:
HY-P0076
Quantity:

TAK-448

Cat. No.: HY-P0076