2. TAK-448

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.

For research use only. We do not sell to patients.

TAK-448 Chemical Structure

TAK-448 Chemical Structure

CAS No. : 1234319-68-6

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Description

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].

IC50 & Target

IC50: 460 pM (KISS1R)[1]
EC50: 632 pM (KISS1R)[1]
In Vivo

TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)
Dosage: 0.01, 0.03, 0.3, 3 mg/kg
Administration: Given i.h.; dosings on day 0 and 28
Result: Had greater anti-tumor effects in VCaP xenograft model.
Clinical Trial
Molecular Weight

1225.36

Formula

C58H80N16O14
CAS No.
SMILES

O=C(N)[C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCCNC(NC)=N)NC([C@H](CC(C)C)NC(NNC([C@H](CC3=CC=CC=C3)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@H]4N(C([C@@H](CC5=CC=C(C=C5)O)NC(C)=O)=O)C[C@H](O)C4)=O)=O)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAK-4481234319-68-6MVT-602TAK448TAK 448MVT602MVT 602Inhibitorinhibitorinhibit

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HY-P0076
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