NOD1/2 antagonist-2
NOD1/2 antagonist-2 (Compound 26BH) is a dual NOD1/NOD2 antagonist (IC50s: 2.36 μM and 4.16 μM for NOD1 and NOD2, respectively). NOD1/2 antagonist-2 inhibits both NF-κB and MAPK inflammatory signaling, thereby sensitizing Paclitaxel (HY-B0015) to suppress Lewis lung carcinoma growth.
For research use only. We do not sell to patients.
- CAS No.: 2101736-25-6
- Formula: C32H37N5O6
- Molecular Weight:587.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NOD1 2.36 μM (IC50) |
NOD2 4.16 μM (IC50) |
Chemical Information
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CAS No. 2101736-25-6
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Molecular Weight 587.67
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Formula C32H37N5O6
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SMILES
O=C(C1=CC(OC2=CC=CC(N(C)C)=C2)=C(NC(COCC3=CC=CC=C3)=O)C=C1N4)N[C@H](CCC(NCCC)=O)C4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang S, et al. Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo. J Med Chem. 2017 Jun 22;60(12):5162-5192. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOD1/2 antagonist-2 Related Classifications
HY-101927 Related Classifications
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