2101736-25-6
Chemical Structure
NOD1/2 antagonist-2
- CAS No.: 2101736-25-6
- Formula:C32H37N5O6
- Molecular Weight:587.67
IUPAC Name: (R)-3-(8-(2-(benzyloxy)acetamido)-7-(3-(dimethylamino)phenoxy)-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-yl)-N-propylpropanamide
InChIKey: MDXBPTFCJUBGJD-RUZDIDTESA-N
SMILES: O=C(C1=CC(OC2=CC=CC(N(C)C)=C2)=C(NC(COCC3=CC=CC=C3)=O)C=C1N4)N[C@H](CCC(NCCC)=O)C4=O
Biological Activity: NOD1/2 antagonist-2 (Compound 26BH) is a dual NOD1/NOD2 antagonist (IC50s: 2.36 μM and 4.16 μM for NOD1 and NOD2, respectively). NOD1/2 antagonist-2 inhibits both NF-κB and MAPK inflammatory signaling, thereby sensitizing Paclitaxel (HY-B0015) to suppress Lewis lung carcinoma growth[1].
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NOD1/2 antagonist-2 | NOD1/2 antagonist-2 (Compound 26BH) is a dual NOD1/NOD2 antagonist (IC50s: 2.36 μM and 4.16 μM for NOD1 and NOD2, respectively). NOD1/2 antagonist-2 inhibits both NF-κB and MAPK inflammatory signaling, thereby sensitizing Paclitaxel (HY-B0015) to suppress Lewis lung carcinoma growth. | |||||||||||||||||||||
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- [1]. Wang S, et al. Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo. J Med Chem. 2017 Jun 22;60(12):5162-5192. [Content Brief]
Keywords
