NOD1/2-IN-1
NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor with an IC50 value of 1.4 nM, as determined by the ADP-Glo assay. NOD1/2-IN-1 blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathways, with IC50 values of 18 nM and 170 nM for NOD1 and NOD2, respectively, thereby reducing inflammatory responses. NOD1/2-IN-1 can be used in studies related to colitis.
For research use only. We do not sell to patients.
- Formula: C22H25N5O2S
- Molecular Weight:423.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NOD1 18 nM (IC50) |
NOD2 170 nM (IC50) |
Chemical Information
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Molecular Weight 423.53
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Formula C22H25N5O2S
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SMILES
COC1=CC2=C(C=C1OCCN(CC)CC)N=CN=C2NC3=CC=C4SC=NC4=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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