TNS4 - tensin 4 Gene

Also Known as CTEN; PP14434

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84951

About TNS4

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,475,834-40,501,623 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 1 paralogue. Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues.

Summary

Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

TNS4 Products (1)

mRNA Protein Name
NM_032865.6 NP_116254.4 tensin-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Biological Process GO Annotation Evidence References Source
involved in protein localization IDA
IDA: Inferred from direct assay
17190795 GOA
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
17190795 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNS4 Protein Structure

SH2

SH2: SH2 domain (449 - 538)

PTB

PTB: Phosphotyrosine-binding domain (582 - 705)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
Protein Preferred Names Protein Names

tensin-4

  • C terminal tensin like

TNS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra
TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 PPP3CA Homo sapiens Q08209-2
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 PPP3CA Homo sapiens Q08209-2
Y2H Array
32296183
Intra
TNS4 Q8IZW8 KAZN Homo sapiens Q674X7-2
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 KAZN Homo sapiens Q674X7-2
Y2H Array
32296183
Intra
TNS4 Q8IZW8 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra
TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra
TNS4 Q8IZW8 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
TNS4 Q8IZW8 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
TNS4 Q8IZW8 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
TNS4 Q8IZW8 TRIM21 Homo sapiens P19474
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 TRIM21 Homo sapiens P19474
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TNS4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81488 TNS4/CTEN Antibody (YA1233) IHC-P Human
HY-P81488A TNS4/CTEN Antibody (YA1233)(PBS only) IHC-P Human
HY-P82489 TNS4/CTEN Antibody (YA2234) WB Human, Mouse, Rat
HY-P82489A TNS4/CTEN Antibody (YA2234)(PBS only) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Parotid Gland Cancer

  • Cancer Of Parotid Gland

  • Parotid Neoplasms

  • Malignant Neoplasm Of The Parotid

  • Malignant Tumor Of Parotid Gland

  • Parotid Cancer

  • Parotid Neoplasm

  • Parotid Gland Carcinoma

  • Cancer Of Parotid

  • Malignant Tumour Of Parotid Gland

  • Parotid Duct Cancer

  • Parotid Ductal Cancer

  • Parotid Glandular Cancer

  • Primary Malignant Neoplasm Of Parotid Gland
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14870 TNS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22348 Tns4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28870 Tns4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNS4 RGD RGD:1310402
Mus musculus TNS4 MGD MGI:2144377
Bos taurus TNS4 VGNC VGNC:36210
Felis catus TNS4 VGNC VGNC:66438
Canis familiaris TNS4 VGNC VGNC:47703
Macaca mulatta TNS4 VGNC VGNC:79432
Others TNS4 NCBI