TNS4/CTEN Antibody (YA2234)
(Synonyms: CTEN; C-terminal tensin-like protein)TNS4/CTEN Antibody (YA2234) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNS4/CTEN.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
TNS4/CTEN Antibody (YA2234) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNS4/CTEN.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 77 kDa
Entrez Gene: 84951 Human ; 217169 Mouse ; 303517 Rat
SwissProt: Q8IZW8 Human ; Q8BZ33 Mouse ; Q4V8I3 Rat
OMIM: 608385 Human
A synthetic peptide of human TNS4
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TNS4/CTEN promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration[1][2][3].
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Subcellular Localization
Cell junction, focal adhesion; Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:It is expressed at low levels (protein level) in the colon (PubMed:19214987, PubMed:19487278) . It is also expressed in the prostate and placenta (PubMed:12154022) .
Induction:By EGF -
Subunit
Interacts (via SH2 domain) with Rho GTPase-activating protein DLC1 (via C-terminus); the interaction is independent of DLC1 tyrosine phosphorylation (PubMed:17190795). Interacts with integrin ITGB1; the interaction displaces tensin TNS3 from the ITGB1 cytoplasmic tail and promotes ITGB1 stability (PubMed:17643115, PubMed:24814316). Interacts (via SH2 domain) with E3 ubiquitin-protein ligase CBL (phosphorylated on 'Tyr-774'); the interaction is enhanced in the presence of EGF and reduces interaction of CBL with EGFR (PubMed:23774213). Interacts (via SH2 domain) with receptor tyrosine kinase MET (when phosphorylated); the interaction increases MET protein stability (PubMed:24814316)
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SwissProt ID
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Synonyms
CTEN; C-terminal tensin-like protein
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Research Field
Signal Transduction
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