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  4. Monoclonal Antibodies Recombinant Antibodies
  5. TNS4/CTEN Antibody (YA1233)

TNS4/CTEN Antibody (YA1233)

Cat. No.: HY-P81488
User Guide for Antibodies Technical Support

TNS4/CTEN Antibody (YA1233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNS4/CTEN.

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Size Prix Stock Quantité
20 μL Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Obtenir un devis  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

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  • Description

  • Références

Description

TNS4/CTEN Antibody (YA1233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNS4/CTEN.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Masse moléculaire
Predicted band size: 77 kDa;
Observed band size: 90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human TNS4
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
Sensitivity Endogenous Pureté Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.290.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Livraison

Shipping with blue ice.
Background
Function：Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316)
Subcellular Localization：Cell junction, focal adhesion; Cytoplasm, cytoskeleton
Expression：
Tissue_specificity:It is expressed at low levels (protein level) in the colon (PubMed:19214987, PubMed:19487278) . It is also expressed in the prostate and placenta (PubMed:12154022) .

Induction:By EGF
Subunit：Interacts (via SH2 domain) with Rho GTPase-activating protein DLC1 (via C-terminus); the interaction is independent of DLC1 tyrosine phosphorylation (PubMed:17190795). Interacts with integrin ITGB1; the interaction displaces tensin TNS3 from the ITGB1 cytoplasmic tail and promotes ITGB1 stability (PubMed:17643115, PubMed:24814316). Interacts (via SH2 domain) with E3 ubiquitin-protein ligase CBL (phosphorylated on 'Tyr-774'); the interaction is enhanced in the presence of EGF and reduces interaction of CBL with EGFR (PubMed:23774213). Interacts (via SH2 domain) with receptor tyrosine kinase MET (when phosphorylated); the interaction increases MET protein stability (PubMed:24814316)
Database

Entrez Gene: 84951 Human

SwissProt: Q8IZW8 Human

OMIM: 608385 Human

Research Field

Signal Transduction
Synonyms
PP14434; CTEN; TNS4; Tensin-4; C-terminal tensin-like protein
Documentation
User Guide for Antibodies (1077 KB)
Références

TNS4/CTEN Antibody (YA1233) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TNS4/CTEN Antibody (YA1233)
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HY-P81488
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