P2RX7 - purinergic receptor P2X 7 Gene

Also Known as P2X7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5027

About P2RX7

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,132,876-121,188,032 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 6.8), skin (RPKM 4.9) and 23 other tissues.

Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

P2RX7 Products (14)

mRNA	Protein	Name
XM_017019367.3	XP_016874856.1	P2X purinoceptor 7 isoform X3
XM_011538419.4	XP_011536721.1	P2X purinoceptor 7 isoform X2
NR_033955.2
NR_033953.2
NR_033954.2
NM_002562.6	NP_002553.3	P2X purinoceptor 7
XM_047428912.1	XP_047284868.1	P2X purinoceptor 7 isoform X1
NR_033950.2
NR_033948.2
NR_033952.2
NR_033956.2
NR_033949.2
NR_033951.2
NM_177427.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	9038151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12107182	GOA
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	9038151	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bleb assembly	IDA IDA: Inferred from direct assay	12107182	GOA
involved in membrane depolarization	IDA IDA: Inferred from direct assay	9038151	GOA
involved in negative regulation of cell volume	IMP IMP: Inferred from mutant phenotype	25651887	GOA
involved in plasma membrane phospholipid scrambling	IDA IDA: Inferred from direct assay	25651887	GOA
involved in pore complex assembly	IDA IDA: Inferred from direct assay	9038151	GOA
involved in pore complex assembly	IMP IMP: Inferred from mutant phenotype	25651887	GOA
involved in positive regulation of bleb assembly	IMP IMP: Inferred from mutant phenotype	25651887	GOA
involved in positive regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	9038151	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22898868	GOA
involved in positive regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	22898868	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	17036048	GOA
involved in positive regulation of monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	25651887	GOA
involved in purinergic nucleotide receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25651887	GOA
involved in response to ATP	IDA IDA: Inferred from direct assay	9038151	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	17785580	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12107182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX7 Protein Structure

P2X_receptor

0
100
200
300
400
425 a.a.

Protein Preferred Names	Protein Names
P2X purinoceptor 7	ATP receptor P2X7 receptor P2Z receptor purinergic receptor P2X, ligand gated ion channel, 7 purnergic receptor P2X 7

P2RX7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	P2RX7	Q99572	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	P2RX7	Q99572	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	P2RX7	Q99572	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	P2RX7	Q99572	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	P2RX7	Q99572	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	P2RX7	Q99572	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	P2RX7	Q99572	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	P2RX7	Q99572	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	P2RX7	Q99572	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	P2RX7	Q99572	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	P2RX7	Q99572	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	P2RX7	Q99572	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	P2RX7	Q99572	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	P2RX7	Q99572	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	P2RX7	Q99572	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

P2RX7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84752	P2RX7 Antibody (YA4449)	WB, IHC-P, FC, ELISA	Human, Mouse, Rabbit
HY-P84752A	P2RX7 Antibody (YA4449)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rabbit

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Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Root Resorption
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Pulmonary Tuberculosis	Tuberculosis, Pulmonary PTB Tuberculosis Pulmonary
Leishmaniasis	Post-Kala-Azar Dermal Leishmaniasis Post Kala-Azar Dermal Leishmaniasis Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis Cutaneous Leishmaniasis Kala-Azar Visceral Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmania Leishmania Infection Leishmaniosis
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Pericarditis
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Mood Disorder	Mood Disorders Episodic Mood Disorder
Tularemia	Francisella Tularensis Infection Deerfly Fever Lemming Fever Ohara Disease Pahvant Valley Plague Rabbit Fever Yatobyo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0298	Clemastine		99.26%	Yes

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09912	P2rx7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09911	P2RX7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09913	P2RX7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	P2RX7	VGNC	VGNC:68672
Canis familiaris	P2RX7	VGNC	VGNC:44212
Mus musculus	P2RX7	MGD	MGI:1339957
Rattus norvegicus	P2RX7	RGD	RGD:3241
Macaca mulatta	P2RX7	VGNC	VGNC:75735
Bos taurus	P2RX7	VGNC	VGNC:32522
Others	P2RX7	NCBI