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KAT14 - lysine acetyltransferase 14 Gene

Also Known as ATAC2; CRP2BP; CSRP2BP; PRO1194; dJ717M23.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57325

About KAT14

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,137,153-18,188,372 (from NCBI)

This gene has 13 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in brain (RPKM 8.7), testis (RPKM 8.1) and 25 other tissues.

Summary

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

KAT14 Products (15)

mRNA	Protein	Name
NM_001384192.3	NP_001371121.2	cysteine-rich protein 2-binding protein isoform 1
NM_001392069.1	NP_001378998.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392070.1	NP_001378999.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392071.1	NP_001379000.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392072.1	NP_001379001.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392073.1	NP_001379002.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392074.1	NP_001379003.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392075.1	NP_001379004.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392076.1	NP_001379005.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392077.1	NP_001379006.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392078.1	NP_001379007.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392079.1	NP_001379008.1	cysteine-rich protein 2-binding protein isoform 3
NM_001392080.1	NP_001379009.1	cysteine-rich protein 2-binding protein isoform 4
NM_001392081.1	NP_001379010.1	cysteine-rich protein 2-binding protein isoform 5
NM_020536.7	NP_065397.4	cysteine-rich protein 2-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	19103755	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA
located in nucleus	IPI IPI: Inferred from physical interaction	10924333	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KAT14 Protein Structure

Acetyltransf_1

0
200
400
600
782 a.a.

Protein Preferred Names	Protein Names
cysteine-rich protein 2-binding protein	ADA2A-containing complex subunit 2

KAT14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73-5	Y2H Prey Pooling	25416956
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
Intra	KAT14	Q9H8E8	ZFY	Homo sapiens	P08048	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	ZFY	Homo sapiens	P08048	Y2H Array	32296183
Intra	KAT14	Q9H8E8	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KAT14	Q9H8E8	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
Intra	KAT14	Q9H8E8	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	KAT14	Q9H8E8	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	KAT14	Q9H8E8	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	KAT14	Q9H8E8	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Array	32296183
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Pooling	19060904
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Array	19060904
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Validated Y2H	32296183
Intra	KAT14	Q9H8E8	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	KAT14	Q9H8E8	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mitochondrial Complex Iv Deficiency, Nuclear Type 19	MC4DN19 Mitochondrial Complex 4 Deficiency, Nuclear Type 19
Buruli Ulcer	Buruli Ulcer, Susceptibility To Buruli Ulcer Disease Mycobacterium Ulcerans Mycobacterium Ulcerans, Susceptibility To Bairnsdale Ulcer Daintree Ulcer Mossman Ulcer Searl Ulcer Searle'S Ulcer Bud
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07073	KAT14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21606	Kat14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28124	Kat14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KAT14	RGD	RGD:1309538
Bos taurus	KAT14	VGNC	VGNC:30397
Felis catus	KAT14	VGNC	VGNC:63022
Mus musculus	KAT14	MGD	MGI:1917264
Canis familiaris	KAT14	VGNC	VGNC:42208
Others	KAT14	NCBI