GNPDA2 - glucosamine-6-phosphate deaminase 2 Gene

Also Known as GNP2; SB52

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 132789

About GNPDA2

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:44,701,795-44,726,556 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 8.8), thyroid (RPKM 8.8) and 25 other tissues.

Summary

The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GNPDA2 Products (3)

mRNA Protein Name
NM_001270880.2 NP_001257809.1 glucosamine-6-phosphate isomerase 2 isoform 2
NM_001270881.2 NP_001257810.1 glucosamine-6-phosphate isomerase 2 isoform 3
NM_138335.3 NP_612208.1 glucosamine-6-phosphate isomerase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glucosamine-6-phosphate deaminase activity IDA
IDA: Inferred from direct assay
12616532 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in UDP-N-acetylglucosamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
26887390 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNPDA2 Protein Structure

Glucosamine_iso

Glucosamine_iso: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase (14 - 216)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

glucosamine-6-phosphate isomerase 2

  • glcN6P deaminase 2

GNPDA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNPDA2 Q8TDQ7 AMDHD2 Homo sapiens Q9Y303
Y2H Array
25416956
Intra
GNPDA2 Q8TDQ7 AMDHD2 Homo sapiens Q9Y303
Anti Tag CoIP
33961781
Intra
GNPDA2 Q8TDQ7 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
GNPDA2 Q8TDQ7 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
GNPDA2 Q8TDQ7 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05572 GNPDA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GNPDA2 MGD MGI:1915230
Bos taurus GNPDA2 VGNC VGNC:29477
Felis catus GNPDA2 VGNC VGNC:62631
Macaca mulatta GNPDA2 VGNC VGNC:72978
Canis familiaris GNPDA2 VGNC VGNC:41332
Rattus norvegicus GNPDA2 RGD RGD:1305521
Others GNPDA2 NCBI