NELFE - negative elongation factor complex member E Gene

Homo sapiens

Also known as RD; RDP; RDBP; D6S45; NELF-E

Gene ID: 7936 | Gene type: protein coding

About NELFE

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,952,087-31,958,971 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 193 orthologues. Ubiquitous expression in testis (RPKM 52.1), ovary (RPKM 20.1) and 25 other tissues.

Summary

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

NELFE Products(1)

mRNA	Protein	Name
NM_002904.6	NP_002895.3	negative elongation factor E

NELFE Protein Structure

RRM_1

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

negative elongation factor E

RD RNA-binding protein

Related Diseases

Diseases

Alias

Immunodeficiency 12

Combined Immunodeficiency Due To Malt1 Deficiency	IMD12
Immunodeficiency, Type 12

Hairy Tongue

Overgrowth Of Filiform Papillae

Tongue, Hairy

Benign Pleural Mesothelioma

Mesothelioma Of Pleura	Benign Neoplasm Of Mesothelial Tissue Of Pleura
Pleural Malignant Mesothelioma

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09203	NELFE Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NELFE	RGD	RGD:1303325
Macaca mulatta	NELFE	VGNC	VGNC:83437
Bos taurus	NELFE	VGNC	VGNC:32002
Felis catus	NELFE	VGNC	VGNC:63774
Mus musculus	NELFE	MGD	MGI:102744

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