GRB14 - growth factor receptor bound protein 14 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2888

About GRB14

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:164,492,417-164,621,482 (from NCBI)

This gene has 7 transcripts (splice variants), 221 orthologues and 4 paralogues. Biased expression in kidney (RPKM 7.9), liver (RPKM 7.8) and 12 other tissues.

Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of Receptor Tyrosine Kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with Insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on Insulin Receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GRB14 Products (2)

mRNA Protein Name
NM_001303422.2 NP_001290351.1 growth factor receptor-bound protein 14 isoform 2
NM_004490.3 NP_004481.2 growth factor receptor-bound protein 14 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
14623073 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
16246733 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16246733 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11278563 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
11278563 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11278563 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRB14 Protein Structure

RA

RA: Ras association (RalGDS/AF-6) domain (107 - 190)

PH

PH: PH domain (237 - 340)

BPS

BPS: BPS (Between PH and SH2) (369 - 417)

SH2

SH2: SH2 domain (439 - 520)

  • 0
  • 100
  • 200
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  • 500
  • 540 a.a.
Protein Preferred Names Protein Names

growth factor receptor-bound protein 14

  • GRB14 adapter protein

GRB14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRB14 Q14449 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
GRB14 Q14449 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
GRB14 Q14449 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
GRB14 Q14449 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05779 GRB14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GRB14 RGD RGD:61869
Bos taurus GRB14 VGNC VGNC:29630
Felis catus GRB14 VGNC VGNC:107550
Macaca mulatta GRB14 VGNC VGNC:73269
Mus musculus GRB14 MGD MGI:1355324
Canis familiaris GRB14 VGNC VGNC:41471
Others GRB14 NCBI