Pyclen dihydrochloride 

Pyclen dihydrochloride forms kinetically and thermodynamically stable nine-coordinate Ln (III) complexes, as well as Mn (II)-based MRI contrast agents. Pyclen-Based Mn(II) Complexes can be used for liver-specific MRI^[1][2].

Pyclen dihydrochloride can form stable, highly luminescent lanthanide (III) complexes, which serve as one- and two-photon biological probes. These complexes stain living human breast cancer cells, exhibit no significant toxicity in the living Danio rerio (zebrafish) model, and enable high-quality in vivo two-photon microscopy imaging^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

279.21

C₁₁H₂₀Cl₂N₄

Solid

C12=CC=CC(CNCCNCCNC2)=N1.Cl.Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Hamon N, et al. Pyclen-Based Ln(III) Complexes as Highly Luminescent Bioprobes for In Vitro and In Vivo One- and Two-Photon Bioimaging Applications. J Am Chem Soc. 2020 Jun 3;142(22):10184-10197.  [Content Brief]

  [2]. Hall RC, et al. Manganese(II) EOB-Pyclen Diacetate for Liver-Specific MRI. ACS Appl Bio Mater. 2022;5(2):451-458.  [Content Brief]