WNT7A - Wnt family member 7A Gene

Also Known as Wnt-7a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7476

About WNT7A

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:13,816,258-13,880,071 (from NCBI)

This gene has 3 transcripts (splice variants), 277 orthologues, 18 paralogues and is associated with 5 phenotypes. Biased expression in brain (RPKM 3.1), placenta (RPKM 2.3) and 9 other tissues.

Summary

This gene is a member of the Wnt gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

WNT7A Products (1)

mRNA	Protein	Name
NM_004625.4	NP_004616.2	protein Wnt-7a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	18986540	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22784633	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	18986540	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12857724	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway, planar cell polarity pathway	IDA IDA: Inferred from direct assay	15802269	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	12857724	GOA
involved in cartilage condensation	IDA IDA: Inferred from direct assay	17202865	GOA
involved in cell proliferation in forebrain	IDA IDA: Inferred from direct assay	12843296	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	15040835	GOA
involved in chondrocyte differentiation	IDA IDA: Inferred from direct assay	17202865	GOA
involved in dendritic spine morphogenesis	IDA IDA: Inferred from direct assay	21670302	GOA
involved in embryonic axis specification	IMP IMP: Inferred from mutant phenotype	16826533	GOA
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	16826533	GOA
involved in embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	16826533	GOA
involved in embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	16826533	GOA
involved in negative regulation of neurogenesis	IDA IDA: Inferred from direct assay	12843296	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15802269	GOA
involved in positive regulation of epithelial cell proliferation involved in wound healing	IDA IDA: Inferred from direct assay	15802269	GOA
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	21670302	GOA
involved in positive regulation of excitatory synapse assembly	IDA IDA: Inferred from direct assay	21670302	GOA
involved in positive regulation of protein metabolic process	IDA IDA: Inferred from direct assay	16805831	GOA
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	18986540	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12857724	GOA
involved in regulation of presynapse assembly	EXP EXP: Inferred from Experiment	20530549	GOA
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	20530549	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	20530549	GOA
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	18413325	GOA
involved in stem cell development	IDA IDA: Inferred from direct assay	12843296	GOA
involved in wound healing, spreading of epidermal cells	IDA IDA: Inferred from direct assay	15802269	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	20530549	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20530549	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20530549	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT7A Protein Structure

wnt

0
100
200
300
349 a.a.

Protein Preferred Names	Protein Names
protein Wnt-7a	proto-oncogene Wnt7a protein

WNT7A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	WNT7A	O00755	Reck	Mus musculus	Q9Z0J1	PLA	30026314
Cross	WNT7A	O00755	Reck	Mus musculus	Q9Z0J1	ITC	30026314
Intra	WNT7A	O00755	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	22784633
Intra	WNT7A	O00755	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	33961781
Intra	WNT7A	O00755	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	WNT7A	O00755	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	WNT7A	O00755	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	WNT7A	O00755	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	WNT7A	O00755	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	WNT7A	O00755	GSN	Homo sapiens	P06396	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly	Fuhrmann Syndrome Bowing Of The Femurs, Aplasia Or Hypoplasia Of The Fibula, And Digital Anomalies Fibular Hypoplasia Or Aplasia-Femoral Bowing-Oligodactyly Syndrome Fuhrmann-Rieger-De Sousa Syndrome FUHRS Fibular Aplasia Hypoplasia Femoral Bowing And Poly- Syn- And Oligodactyly
Ulna And Fibula, Absence Of, With Severe Limb Deficiency	Schinzel Phocomelia Syndrome Aarrs Limb/Pelvis-Hypoplasia/Aplasia Syndrome LPHAS Schinzel Type Phocomelia Absence Of Ulna And Fibula With Severe Limb Deficiency Al-Awadi/Raas-Rothschild Syndrome Al Awadi-Raas-Rothschild Syndrome Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome Aplasia/Hypoplasia Of Limbs And Pelvis Congenital Absence Of Ulna And Fibula Severe Limb Deficit Phocomelia, Schinzel Type Al-Awadi-Raas-Rothschild Syndrome Ulna And Fibula Absence Of With Severe Limb Deficiency Limb Pelvis Hypoplasia Aplasia Syndrome Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Phocomelia	Phocomelia Syndrome
Mullerian Aplasia And Hyperandrogenism	Mullerian Duct Failure And Hyperandrogenism Wnt4 Deficiency Müllerian Aplasia And Hyperandrogenism Biason-Lauber Syndrome Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome Mayer-Rokitansky-Küster-Hauser-Like Syndrome Müllerian Duct Failure Wnt4 Müllerian Aplasia Wnt4 Müllerian Aplasia And Ovarian Dysfunction MULLAPL Wnt4 Mullerian Aplasia And Ovarian Dysfunction
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Mayer-Rokitansky-Kuster-Hauser Syndrome	Mrkh Syndrome Rokitansky Syndrome Mullerian Aplasia Mrkh Anomaly Congenital Absence Of Uterus And Vagina Congenital Absence Of The Uterus And Vagina Genital Renal Ear Syndrome Mayer-Rokitansky-Küster-Hauser Syndrome Mullerian Dysgenesis Müllerian Agenesis Rokitansky Kuster Hauser Syndrome MRKH Mullerian Aplasia/Dysgenesis Von Mayer-Rokitansky-Kuster Anomaly Mrk Anomaly Uterus Bipartitus Solidus Rudimentarius Cum Vagina Solida Cauv Mullerian Agenesis Aplasia Of The Mullerian Ducts Mullerian Duct Failure Müllerian Aplasia Rokitansky-Kuster-Hauser Syndrome RKH SYNDROME
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Tibia, Hypoplasia Or Aplasia Of, With Polydactyly	Hypoplastic Or Aplastic Tibia With Polydactyly Absence Of Tibia With Polydactyly Tibial Hemimelia-Polysyndactyly-Triphalangeal Thumb Syndrome THYP Tibial Hemimelia-Polydactyly-Triphalangeal Thumbs With Fibular Dimelia Absent Tibia-Polydactyly Syndrome Werner Mesomelic Syndrome Hypoplastic Tibiae-Postaxial Polydactyly Syndrome Polydactyly With Absent Tibia Werner Mesomelic Spectrum Hypoplasia Or Aplasia Of Tibia With Polydactyly Wms Tibia, Hypoplasia Of, With Polydactyly
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Persistent Mullerian Duct Syndrome	Persistent Müllerian Duct Syndrome Pmds Persistent Oviduct Syndrome Persistent Muellerian Duct Syndrome Female Genital Ducts In Otherwise Normal Male Hernia Uteri Inguinale Persistent Mullerian Duct Syndrome, Types 1 And 2 Persistent Mullerian Derivatives
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105634A	Nomegestrol acetate	Agonist	99.73%	Yes

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D1474	WNT7A-IN-1 sodium	Inhibitor	98.05%	Unkown
HY-170411	WNT7A-IN-1	Inhibitor	99.66%	Unkown
HY-181160	JNK3/Wnt/β-catenin modulator-1		/	Unkown
HY-RS15840	WNT7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WNT7A	RGD	RGD:69079
Bos taurus	WNT7A	VGNC	VGNC:36963
Macaca mulatta	WNT7A	VGNC	VGNC:78799
Felis catus	WNT7A	VGNC	VGNC:102732
Mus musculus	WNT7A	MGD	MGI:98961
Canis familiaris	WNT7A	VGNC	VGNC:48428
Others	WNT7A	NCBI